Newest Articles
The glialbiologist's toolboxAn amazing array of tools both old and new are available to investigate the function of astrocytes and microglia. Guttenplan and Liddelow discuss tools available to study the physiology and pathophysiology of these cells both in vivo and in culture systems.
Cohesin mediates NF-κB–induced HSC differentiationChen et al. identify Rad21/cohesin as a critical mediator of inflammation/NF-κB–induced differentiation of hematopoietic stem cells (HSCs). Aging-associated increases in inflammation select for HSCs with disrupted or naturally reduced Rad21/cohesin expression exhibiting increased self-renewal and myeloid-biased differentiation: two hallmark features of the aging hematopoietic system.
Tissue residency program of MAIT cellsSalou et al. wondered what could differentiate MAIT and NKT cells, if not for TCR specificity. Once split according to RORγt and T-bet–expressing subsets, MAIT and NKT share almost identical transcriptional programs acquired in the thymus, which result in specific tissue residency patterns.
Vaccines: An achievement of civilization, a human right, our health insurance for the futureThe value and social challenges of vaccination.
Eran Elinav: Beyond the microbiomeEran Elinav: Beyond the microbiome
Neuroimmunology: Microglia and beyondIn recent years, there has been great progress in the field of neuroimmunology, implicating both parenchymal macrophages (microglia) and meningeal immunity in homeostatic brain function. In this review, Norris and Kipnis discuss these two immune compartments and how they are critically segregated to preserve homoeostasis.
ICOSLG deficiencyRoussel et al. identify the first patient with autosomal recessive deficiency in ICOSLG, the gene encoding the ligand for ICOS. The missense allele impairs cell surface expression of ICOSL, compromises T–B lymphocyte costimulation, and results in combined immunodeficiency.
Ezh2 inhibition in Kras-driven NSCLCKras-driven non–small-cell-lung cancers (NSCLCs) are a leading cause of death with limited therapeutic options. Serresi et al. show that inhibiting Ezh2 in orthotopic KrasG12D-driven NSCLC unleashes an inflammatory response rewiring tumor progression and amplifying associated vulnerabilities that could be therapeutically exploited.
Distinct subpopulations of CAFs in breast cancerRaz et al. demonstrate that the expression of PDGFRα distinguishes two functional CAF populations in breast tumors and lung metastases and identify a subpopulation of CAFs that are specifically recruited to the tumor microenvironment from mesenchymal stromal cells in the BM.
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Current Issue
February 4, 2019
Volume 216, No. 2
