- CD72 negatively regulates anti-Sm/RNP B cells
Akatsu and colleagues show that CD72 specifically recognizes Sm/RNP, a lupus-related self-antigen and an endogenous TLR7 ligand, and inhibits B cell responses to Sm/RNP. In mice, CD72 prevents production of anti-Sm/RNP antibodies crucial for lupus development.
- Diurnal control of lymphocyte recirculation
Suzuki et al. show that neural inputs to β2-adrenergic receptors expressed on lymphocytes generate the diurnal variation in the frequency of lymphocyte egress from lymph nodes, which is reflected in the magnitude of the adaptive immune response.
- SCID zebrafish for cell transplantation
Moore and colleagues present new strains of optically clear immune-deficient zebrafish that allow for dynamic imaging of regeneration and tumor progression at single-cell resolution in live animals.
- HDAC7 is essential for B cell development
The histone deacetylase HDAC7 interacts with and represses myeloid and T cell genes in pro–B cells. HDAC7 deletion blocks early B cell development and results in severe lymphopenia.
- Gut microbiota and spinal cord injury
Kigerl et al. show that spinal cord injury causes profound changes in gut microbiota and that these changes in gut ecology are associated with activation of GALT immune cells. They show that feeding mice probiotics after SCI confers neuroprotection and improves functional recovery.
- MAIT cells and monocyte differentiation
Cowley and Meierovics show that mucosa-associated invariant T (MAIT) cells promote the differentiation of monocytes into monocyte-derived dendritic cells during Francisella tularensis LVS pulmonary infection.
- A new mechanism of loss-of-function polymorphism T232 in FcγRIIB
Xu et al. show that the lupus-associated polymorphism FcγRIIB-T232 has structural changes of the TM domain that reduces lateral mobility and inhibitory functions.