Newest Articles
IgM’s exit routeIgM leaves the lymph node via the microarchitecture of the fibroblastic reticular cell conduit.
All (animal) models (of neurodegeneration) are wrong. Are they also useful?Ransohoff discusses why animal models have uniformly failed to predict success in neurodegenerative clinical trials.
Sensing danger through a “finger”Cellular nucleic acid–binding protein (Cnbp) regulates IL-12β transcription and IL-12–driven, Th1-mediated immune responses.
Conditional versus constitutive γδ T cell knockoutThe authors present a genetic mouse model for conditional depletion of γδ T cells, confirming the fetal origin and persistence of Tγδ17 cells. They show differential phenotypes after acute depletion versus constitutive γδ T cell deficiency in imiquimod-induced psoriasis.
TLR8 and miR-21 contribute to neuropathic painTLRs are known to be essential for innate and adaptive immunity. Zhang et al. show the involvement of TLR8 and its endogenous ligand miR-21 in neuropathic pain via inducing ERK-dependent proinflammatory mediators’ production and neuronal hyperexcitability in the DRG.
TLR8: No gain, no painmiR21-mediated activation of TLR8 controls neuropathic pain.
CNBP mediated IL-12 transcriptionThese studies reveal a previously unrecognized role for Cnbp as a novel transcriptional regulator engaged downstream of innate immune receptors controlling the c-Rel–IL-12–Th1 axis, which has important implications for both host defense and inflammatory disease.
TrIP regulates T cell activationThis study demonstrates a role for the transmembrane regulator of PI3K (TrIP) in restricting early T cell activation, at least in part through effects on PI3K. It is also shown that levels of TrIP decrease preceding full T cell activation.
Conduits transport IgM in reactive lymph nodesIgM provides early protection against pathogens. How IgM is exported out of lymph nodes remains unknown. Thierry et al. report that B cells utilize a system of paracortical conduits to rapidly export their IgM to the periphery.
Endothelial cells control thymocyte egressThymic emigration is essential for establishing T cell immunity. We show the requirement for LTβR segregates from its control of medullary epithelium. Instead, our study demonstrates LTβR expression by the endothelium acts to rate limit thymocyte egress via perivascular routes.
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Current Issue
February 4, 2019
Volume 216, No. 2
