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Newest Articles

  • Interleukin-10 stiffens the heart
    Interleukin-10 stiffens the heart

    Cardiac-resident macrophages are a diverse population of cells that have a critical role in the pathogenesis of heart failure. A new understanding of communication between macrophages and cardiac fibroblasts could lead to novel therapeutic strategies for heart failure with preserved ejection function.

    Daniela Cihakova
    Insights | January 18, 2018
  • Sequential BMP7/TGF-β1 signaling and microbiota instruct mucosal Langerhans cell differentiation
    Developmental mechanisms of mucosal LCs

    Capucha et al. demonstrate that mucosal Langerhans cell (LC) differentiation from pre–dendritic cells and monocytes involves consecutive BMP7 and TGF-β1 signaling in separate anatomical locations. Moreover, mucosal microbiota regulates the development of LCs that in turn shape microbial and immunological homeostasis.

    Tal Capucha ... Avi-Hai Hovav
    Article | January 17, 2018
  • Cbfβ2 controls differentiation of and confers homing capacity to prethymic progenitors
    Cbfβ2 controls prethymic progenitor development

    Tenno et al. show that an evolutionarily conserved alternative splicing event in the Cbfb gene generates Cbfβ2, which forms a functionally distinct transcription factor complex underlying the differentiation of extrathymic T cell progenitors, including induction of the principal thymus-homing receptor, Ccr9.

    Mari Tenno ... Ichiro Taniuchi
    Article | January 17, 2018
  • Cardiac macrophages promote diastolic dysfunction
    Cardiac macrophages promote diastolic dysfunction

    Hulsmans et al. show that cardiac macrophages expand in left ventricular diastolic dysfunction, a hallmark of heart failure with preserved ejection fraction (HFpEF) and cardiac aging. In HFpEF, macrophages shift toward a profibrotic subset that promotes ventricular stiffness.

    Maarten Hulsmans ... Matthias Nahrendorf
    Article | January 16, 2018
  • Targeting IRF3 as a YAP agonist therapy against gastric cancer
    IRF3 as a YAP agonist

    Jiao et al. show that the key player of antiviral immunity IRF3 binds to and promotes the transactivation of the YAP–TEAD4 complex to coregulate transcription of Hippo pathway target genes and that therapeutic targeting of IRF3 suppresses YAP-driven gastric cancer.

    Shi Jiao ... Zhaocai Zhou
    Article | January 16, 2018
  • Development of intestinal M cells and follicle-associated epithelium is regulated by TRAF6-mediated NF-κB signaling
    NF-κB regulates the development of M cells

    TRAF6 is essential for RANK-mediated NF-κB activation and is involved in the development of several types of cells. Kanaya et al. demonstrate that RANK–TRAF6-mediated NF-κB is essential for the development of M cells and FAE.

    Takashi Kanaya ... Hiroshi Ohno
    Article | January 16, 2018
  • Guidance of super-enhancers in regulation of IL-9 induction and airway inflammation
    Role of super-enhancers in Th9 induction

    Xiao et al. demonstrate that formation of super-enhancers at Il9 locus is critical for robust IL-9 expression and Th9 cell induction, and assembly of Il9 super-enhancers is driven by OX40-mediated chromatin acetylation.

    Xiang Xiao ... Xian Chang Li
    Article | January 16, 2018
  • Ontogeny of human mucosal-associated invariant T cells and related T cell subsets
    Ontogeny of human MAIT cells

    There are very few human MAIT cells in cord blood. Ben Youssef et al. show that they slowly expand during childhood and point to a critical role of the TCRαβ repertoire in determining their unique ability to recognize MR1-restricted microbial antigens.

    Ghada Ben Youssef ... Sophie Caillat-Zucman
    Article | January 16, 2018
  • Bile acids in glucose metabolism in health and disease
    Bile acids in glucose metabolism in health and disease

    Bile acids were recently shown to regulate glucose homeostasis through diverse mechanisms involving the host and its microbiome. Herein, Shapiro et al. discuss the impact of bile acids on normal and impaired glycemic responses, including potential therapeutic implications in treating hyperglycemia and diabetes.

    Hagit Shapiro ... Eran Elinav
    Review | January 16, 2018
  • LIGHT–HVEM signaling in keratinocytes controls development of dermatitis
    HVEM controls dermatitis

    Factors that control skin inflammation are still being defined. Herro et al. demonstrate that the tumor necrosis factor superfamily protein LIGHT acts on keratinocytes via its receptor HVEM to promote characteristic features of atopic dermatitis, including epidermal hyperplasia and production of periostin.

    Rana Herro ... Michael Croft
    Brief Definitive Report | January 16, 2018

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The Journal of Experimental Medicine: 215 (4)

Current Issue

April 2, 2018
Volume 215, No. 4

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Online ISSN: 1540-9538
Print ISSN: 0022-1007

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