Newest Articles
ADAM17 and IL-6 trans-signaling in intestinal tumorigenesisSchmidt et al. show that loss of the membrane-bound metalloprotease ADAM17 led to impaired intestinal cancer development in the murine APCmin/+ model, which also depended on IL-6 trans-signaling via the soluble IL-6R and could be blocked by the specific IL-6 trans-signaling inhibitor sgp130Fc.
IL-7 regulates lymphocyte entry into lymph nodesYang et al. identify a new function for IL-7 in permitting efficient entry of T and B lymphocytes into lymph nodes. Maintenance of ILC3s by IL-7 is implicated because ILC3-deficient chimeras exhibit similar trafficking defects.
Modeling human bone marrow niche in miceAbarrategi et al. summarize the methods used for human hematopoietic cell xenotransplantation and their milestones. They also discuss the latest approaches in generating humanized BM tissues in mice to study human normal and malignant hematopoiesis.
ZEB1 and miR-200s promote memory CD8+ T cell developmentGuan et al. identify genetic cooperativity between the transcription factor ZEB1 and the miR-200 family in memory CD8+ T cell development, which contrasts with that observed in the EMT. This study also shows that ZEB1 and its closely related homologue, ZEB2, play functionally distinct roles in CD8+ T cell differentiation.
Predicting AID off-targets: A step forwardIn this issue of JEM, Álvarez-Prado et al. designed a DNA capture library allowing them to identify 275 genes targeted by AID in mouse germinal center B cells. Using the molecular features of these genes to feed a machine-learning algorithm, they determined that high-density RNA PolII and Spt5 binding—found in 2.3% of the genes—are the best predictors of AID specificity.
Conditional deletion of BACE1 in AD miceThis study uses mouse models to answer how BACE1 inhibitory drugs will be beneficial to Alzheimer’s patients. Hu et al. find that sequentially increased deletion of BACE1 in one adult Alzheimer’s mouse model reverses preexisting amyloid plaques and mitigates synaptic failures.
Sox7 abnormalizes high-grade glioma vesselsAntiangiogenic therapy has a clinical benefit in only a subpopulation of high-grade glioma (HGG) patients. Kim et al. show that in an orthotopic HGG model, high levels of Sox7 in tumor vessels correlate with improved survival by anti-VEGFR2 antibody, suggesting a potential mechanism of heterogeneous therapeutic outcome to antiangiogenic therapy.
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Current Issue
June 4, 2018
Volume 215, No. 6
