Newest Articles
Interleukin-10 stiffens the heartCardiac-resident macrophages are a diverse population of cells that have a critical role in the pathogenesis of heart failure. A new understanding of communication between macrophages and cardiac fibroblasts could lead to novel therapeutic strategies for heart failure with preserved ejection function.
Developmental mechanisms of mucosal LCsCapucha et al. demonstrate that mucosal Langerhans cell (LC) differentiation from pre–dendritic cells and monocytes involves consecutive BMP7 and TGF-β1 signaling in separate anatomical locations. Moreover, mucosal microbiota regulates the development of LCs that in turn shape microbial and immunological homeostasis.
Cbfβ2 controls prethymic progenitor developmentTenno et al. show that an evolutionarily conserved alternative splicing event in the Cbfb gene generates Cbfβ2, which forms a functionally distinct transcription factor complex underlying the differentiation of extrathymic T cell progenitors, including induction of the principal thymus-homing receptor, Ccr9.
Cardiac macrophages promote diastolic dysfunctionHulsmans et al. show that cardiac macrophages expand in left ventricular diastolic dysfunction, a hallmark of heart failure with preserved ejection fraction (HFpEF) and cardiac aging. In HFpEF, macrophages shift toward a profibrotic subset that promotes ventricular stiffness.
IRF3 as a YAP agonistJiao et al. show that the key player of antiviral immunity IRF3 binds to and promotes the transactivation of the YAP–TEAD4 complex to coregulate transcription of Hippo pathway target genes and that therapeutic targeting of IRF3 suppresses YAP-driven gastric cancer.
NF-κB regulates the development of M cellsTRAF6 is essential for RANK-mediated NF-κB activation and is involved in the development of several types of cells. Kanaya et al. demonstrate that RANK–TRAF6-mediated NF-κB is essential for the development of M cells and FAE.
Role of super-enhancers in Th9 inductionXiao et al. demonstrate that formation of super-enhancers at Il9 locus is critical for robust IL-9 expression and Th9 cell induction, and assembly of Il9 super-enhancers is driven by OX40-mediated chromatin acetylation.
Ontogeny of human MAIT cellsThere are very few human MAIT cells in cord blood. Ben Youssef et al. show that they slowly expand during childhood and point to a critical role of the TCRαβ repertoire in determining their unique ability to recognize MR1-restricted microbial antigens.
Bile acids in glucose metabolism in health and diseaseBile acids were recently shown to regulate glucose homeostasis through diverse mechanisms involving the host and its microbiome. Herein, Shapiro et al. discuss the impact of bile acids on normal and impaired glycemic responses, including potential therapeutic implications in treating hyperglycemia and diabetes.
HVEM controls dermatitisFactors that control skin inflammation are still being defined. Herro et al. demonstrate that the tumor necrosis factor superfamily protein LIGHT acts on keratinocytes via its receptor HVEM to promote characteristic features of atopic dermatitis, including epidermal hyperplasia and production of periostin.
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Current Issue
April 2, 2018
Volume 215, No. 4
