- Infection-induced thymic atrophy dampens immunity
Kugler et al. show that systemic infection with Toxoplasma gondii triggers a long-term impairment in thymic function, which leads to an immunodeficient state reflected in decreased antimicrobial resistance.
- STAT1 regulates MZ B cell antibody response
Chen et al. show that STAT1 positively regulates TLR- and S. pneumoniae–induced IgM responses of MZ B cells through up-regulation of Prdm1 expression, and STAT1 is crucial for MZ B cell–mediated clearance of blood-borne S. pneumoniae infection.
- RAMDs as CD8+ TRM niches in the lung
Takamura et al. show that most lung CD8+ TRM cells are not maintained in the inducible bronchus-associated lymphoid tissue (iBALT) but are maintained in specific niches created at the site of tissue regeneration, which are termed as repair-associated memory depots (RAMDs).
- Local competition regulates the skin TRM cell pool
Muschaweckh et al. show that antigen presentation in the skin regulates the generation of tissue-resident memory T (TRM) cells by orchestrating local competition of antiviral CD8+ T cells, revealing a mechanism to fine-tune the repertoire of regional pools of TRM cells.
- B1 B cells become chronic lymphocytic leukemia
Hayakawa et al. show that distinctive B-lineage progression from B-1 development allows for generation of B1a cells with restricted BCRs and self-renewal capacity, both contributing to potential for CLL progression.
- NLRP2 controls age-associated maternal fertility
Kuchmiy et al. show that Nlrp2, while dispensable for regulation of inflammasome activation, controls maternal fertility with progressing age, playing an unexpected and critical role in maintaining oocyte quality later in life.
- Distinct precursors for CD1c+ and CD141+ DCs
Breton et al. identify CD172a as a lineage marker that distinguishes human cDC precursor (pre-cDC) subpopulations committed to the CD1c+ lineage (CD172a+ pre-cDCs) or CD141+ lineage (CD172a− pre-cDCs).
- Tissue-specific layered defense against respiratory virus infection
Abboud et al. reveal the striking and unexpected spatial organization of central- versus effector-like memory cells within the infected lung tissue and how cooperation between these two subsets contributes to host defense.