Newest Articles
Repressing the repressor: Ezh2 mediates macrophage activationIn this issue of JEM, Zhang et al. show that the suppressive epigenetic enzyme Ezh2 is an important regulator of macrophage activation. The absence of Ezh2 leads to reduced cytokine secretion and suppresses macrophage-dependent disease development. They identify the antiinflammatory factor Socs3 as an important target for Ezh2 and thus show that regulation of suppressive histone modifications controls macrophage activation in disease.
Dual therapy for Aβ amyloidosis in ADChiang et al. make a notable contribution in Alzheimer disease (AD) therapeutics in a thorough and rigorous study demonstrating superior efficacy of dual therapy against Aβ in a mouse model of amyloid β deposition.
SHP-1 regulates HSC quiescence via TGF-β signalingMegakaryocytes are known for hematopoietic stem cell (HSC) regulation. Here, Jiang et al. show that megakaryocytes cooperate with Schwann cells in bone marrow niche and that SHP-1 regulates HSC quiescence by coordinating TGF-β signaling in megakaryocyte niche.
MHC class I temperature exchangeLuimstra et al. describe a temperature-mediated peptide exchange method for generating many different epitope-specific MHC class I multimers in parallel. This simple and versatile technology allows fast and efficient production of MHC I reagents for immune monitoring of T cell responses.
Role of type I interferons in tuberculosisType I interferons have been implicated in the pathogenesis of tuberculosis. Herein, Moreira-Teixeira et al. discuss mechanistic and contextual factors that determine the role of type I interferons during Mycobacterium tuberculosis infection, from human disease to experimental models of tuberculosis.
Biology and function of peripheral macrophages in the brainPeripherally derived macrophages can engraft the brain in the context of chronic microglia loss without brain irradiation and maintain a unique transcriptional signature throughout different experimental contexts.
Asxl1 mutant knock-in mouse model mimicking CHIPNagase and Inoue et al. generated a novel Asxl1 mutant mouse model to mimic clonal hematopoiesis and myelodysplastic syndromes caused by ASXL1 mutations and elucidated the effects of mutant versus wild-type ASXL1 on hematopoiesis, gene expression, and chromatin state.
CIN85 as novel candidate gene for X-linked antibody deficiencyDespite the numerous cellular functions attributed to the scaffolding protein CIN85, Keller et al. show that an inactivating germline deletion within the human CIN85 gene causes a remarkably specific defect in the activation of B lymphocytes, preventing proper immune responses.
Benefits of dual anti-Aβ treatment in APP miceChiang et al. show that combining two complementary approaches for Aβ reduction improved cognitive function in a mouse model of amyloidosis relative to either treatment alone. Efficacy corresponded with restoration of mTOR signaling, TFEB expression, and autophagic flux, suggesting additional targets for future polytherapy in AD.
Macrophage/microglia Ezh2 mediates autoimmunityH3K27me3 is known to silence gene expression. Zhang et al. reveal that, rather than functioning as a repressor, Ezh2 or H3K27me3 specifically mediates toll-like receptor (TLR)-induced proinflammatory responses in macrophages/microglia, in which Ezh2 directly targets Socs3, consequently mediates TLR-induced NF-κB activation, and facilitates autoimmune inflammation.
Pages
Current Issue
August 6, 2018
Volume 215, No. 8
