Newest Articles
RIC noninvasively promotes hematoma resolutionIntracerebral hemorrhage is a devastating neurological injury that produces poor patient outcomes. In this report, Vaibhav et al. demonstrate that remote ischemic post-conditioning noninvasively accelerates hematoma resolution by enhancing AMPK-dependent alternative macrophage activation.
Sox12 induces pT reg differentiationTanaka et al. show that Sox12, a member of SoxC family, is induced by TCR-NFAT signaling in T cells, binds to the Foxp3 promoter and drives its transcription, and induces the differentiation of T reg cells in the periphery during colitis.
Rapid CLIP–MHC II dissociation in autoimmunitySpontaneous CLIP dissociation from an autoimmunity-associated MHC II protein enhances presentation of peptides released by insulin-producing β cells. Presentation of such extracellular peptides does not require endosomal antigen processing and augments islet infiltration by CD4 T cells.
ACE inhibitors block neurotoxic DNRAbsNestor et al. examine how lupus antibodies that enter the brain cause neuronal dysfunction and cognitive impairment. The results show that activated microglia are critical for neuronal damage and that inhibiting them can preserve neuronal function and cognition.
One-step generation of monoclonal B cell miceJacobsen et al. describe a method to quickly generate mice carrying monoclonal immunoglobulins using CRISPR–Cas9-based genome editing in zygotes. Both chains are targeted in tandem into the Igh locus, allowing for isotype switching, somatic hypermutation, and affinity maturation.
Cell circuits control B cell developmentB cell development is characterized by well-defined transitions. Fistonich et al. demonstrate that two distinct cell circuits formed between proB, preB, and IL-7+ cells regulate the size and quality of B cell progenitors and control B cell development.
Decoy TLR5 reduces Aβ plaquesChakrabarty et al. show that human TLR5 ectodomain reduces amyloid β (Aβ) plaques by direct interaction with Aβ, demonstrating the feasibility of such immune decoy receptor strategies as potential biotherapies in Alzheimer’s disease.
Stem-like CD8+ T cells in solid tumorsCD8+ T cells infiltrating tumors are largely dysfunctional. Brummelman and Mazza et al. identify partially exhausted CXCR5+ TIM-3– CD8+ T cells with enhanced stem-like properties and cytotoxicity infiltrating human solid tumors. These cells express candidate immunotherapeutic targets (PD-1, TIGIT and CD27) for their reinvigoration.
IRF9 deficiencyWe report a child with inherited, complete IRF9 deficiency who suffered from life-threatening influenza pneumonitis. IRF9 deficiency disrupts the activation of ISGF3 and impairs but does not abolish cellular responses to type I IFNs, as some ISGs are induced.
NGLY1-NRF1 pathway regulates mitophagy and inflammationYang et al. show that NGLY1, a deglycosylation enzyme, regulates mitochondrial homeostasis and mitophagy through transcription factor NRF1. In the absence of NGLY1, cellular clearance of damaged mitochondria by mitophagy is impaired, resulting in chronic activation of innate immune nucleic acid–sensing pathways.
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Current Issue
December 3, 2018
Volume 215, No. 12
