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A
A, ampere
Å, angstrom
aa, amino acid(s)
AIDS, acquired immune deficiency syndrome
APC, antigen-presenting cell
ATP, adenosine triphosphate (also ADP, AMP, CTP, UDP, etc.)
B
bp, basepair
BM, bone marrow
Bq, Becquerel
BrdU, 5-bromo-2'deoxyuridine
BSA, bovine serum albumin
C
C, complement
C region, constant region of Ig
cAMP, cyclic AMP
cDNA, complementary DNA
CFA, complete Freund's adjuvant
CFSE, carboxyfluorescein diacetate succinimidyl ester
CFU, colony-forming unit
Ci, curie
cM, centimorgan (but morgan)
CMV, cytomegalovirus
Con A, concanavalin A
cpm, counts per minute
CSF, colony-stimulating factor
CTL, cytotoxic T lymphocyte
D
d, day
D region, diversity region of Ig or TCR
DC, dendritic cell
DAPI, 6'-diamidino-2-phenylindole
DME, Dulbecco's modified Eagle's medium
DMEM, Dulbecco's minimum essential medium
dpm, disintegrations per minute
DMSO, dimethylsulfoxide
DNA, deoxyribonucleic acid
DNase, deoxyribonuclease
DNP, dinitrophenyl
E
E, erythrocyte (e.g., E-rosette)
EBV, Epstein-Barr virus
ED50, 50% effective dose
EDTA, ethylenediaminetetraacetic acid
EGTA, ethyleneglycol-bis (β-aminoethyl ether)- N, N, N',N'-tetraacetic
acid
ELISA, enzyme-linked immunosorbent assay
ELISPOT, enzyme-linked immunospot
ER, endoplasmic reticulum
E/T ratio, effector–target ratio
F
FBS, fetal bovine serum
FCS, fetal calf serum
FITC, fluorescein isothiocyanate
fMLP, formyl-methionyl-leucyl-phenylalanine
G
g, gram
g, unit of gravity
GAPDH, glyceraldehyde 3-phosphate dehydrogenase
GFP, green fluorescent protein
GM-CSF, granulocyte/macrophage colony-stimulating factor
H
h, hour
H chain, heavy chain of Ig
HAT, hypoxanthine, aminopterin, thymidine
HBSS, Hanks' balanced salt solution
Hepes, N-2-hydroxyethylpiperazine-N'-2-ethane sulfonic acid
HIV, human immunodeficiency virus
HLA, human histocompatibility leukocyte antigens
HPLC, high performance liquid chromatography
HSV, herpes simplex virus
HTLV, human T lymphocyte virus
I
Id, idiotype
ID50, 50% infective or inhibiting dose
IEF, isoelectric focusing
IFA, incomplete Freund's adjuvant
IFN, interferon (e.g., IFN-γ)
Ig, immunoglobulin
IL, interleukin (e.g., IL-2)
i.m., intramuscular(ly)
IMDM, Iscove's modified Dulbecco's medium
i.p., intraperitoneal(ly)
IU, international unit
i.v., intravenous(ly)
J
J region, joining region of Ig or TCR
JAK, Janus kinase
K
kb, kilobase
kD, kilodalton
KLH, keyhole limpet hemocyanin
KO, knockout
L
L chain, light chain of Ig
LAK, lymhokine-activated killer
LD50, 50% lethal dose
LFA, lymphocyte function associated
LGL, large granular lymphocytes
LN, lymph node
LPS, lipopolysaccharide
LTR, long terminal repeat
M
m, meter
M, molar
mAb, monoclonal antibody
2-ME, 2-mercaptoethanol
MEM, minimum essential medium
MHC, major histocompatability complex
ml, milliliter (but liter)
MLC, mixed lymphocyte culture
MLR, mixed leukocyte reaction
Mls, minor lymphocyte stimulating
mo, month
mol, mole
mol wt, molecular weight
Mr, relative molecular mass
N
n, number in study or group
N, normal (concentration of ionizable groups)
ND, not determined
NFAT, nuclear factor of activated T cells
NF-κB, nuclear factor κB
NK cell, natural killer cell
NP-40, Nonidet P-40
NS, not significant
nt, nucleotide
O
OD, optical density
osM, osmolar
osmol, osmole(s)
OVA, ovalbumin
P
PAGE, polyacrylamide gel electrophoresis
PBL, peripheral blood lymphocyte
PBMC, peripheral blood mononuclear cell
PBS, phosphate-buffered saline
PCR, polymerase chain reaction
PE, phycoerythrin
PFU, plaque-forming unit
PHA, phytohemagglutinin
Pipes, piperazine-N, N'-bis(2-ethane sulfonic acid)
PMA, phorbol myristate acetate
PMN, polymorphonuclear leukocytes
PMSF, phenylmethylsulfonyl fluoride
R
r, recombinant (e.g., rIFN-γ)
R, receptor (e.g, IL-2R)
RAG, recombination activating gene
RBC, red blood cell
RFLP, restriction fragment length polymorphism
RIA, radioimmunoassay
RNA, ribonucleic acid
RNase, ribonuclease
RT, reverse transcription
S
s, seconds
s, sedimentation coefficient
S, Svedberg unit of sedimentation coefficient
s.c., subcutaneous(ly)
SCID, severe combined immunodeficiency
SD, standard deviation
SDS, sodium dodecyl sulfate
SE, standard error
SEM, standard error of the mean
SSC, standard saline citrate
STAT, signal transducer and activator of transcription
T
t1/2, half-life, half-time
TCA, trichloroacetic acid
TCR, T cell receptor for antigen
TdR, thymidine deoxyribose (also, UdR, AdR, etc.)
TFA, trifluoroacetic acid
TGF, transforming growth factor
Th, T helper cell
TLC, thin layer chromatography
TNF, tumor necrosis factor (α)
TNP, trinitrophenyl
Tris, tris (hydroxymethyl) aminomethane
U
U, unit
UV, ultraviolet
V
V, volt
V region, variable region of Ig
vol, volume
W
W, watt
wk, week
wt, weight
WT, wild-type
Y
yr, year
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