- Antibody-secreting plasma cells persist for decades in human intestine
This study provides a definite answer to the long-standing question concerning the longevity of the secretory antibody response. Landsverk et al. show that antigenic attrition affects a minor plasma cell subset and that distinct plasma cells are likely maintained for life in the human small intestine.
- Characterization of meningeal type 2 innate lymphocytes and their response to CNS injury
Immune responses to central nervous system (CNS) injuries are multifaceted, but their contributions are incompletely understood. Here, Gadani et al. describe type 2 innate lymphocytes as novel meningeal-resident cells, characterizing their transcriptional profile and response to CNS injury.
- CNS-targeted autoimmunity leads to increased influenza mortality in mice
Glenn et al. show that EAE induction impairs influenza immune responses, worsens influenza pathology, and is marked by early EAE-induced recruitment of suppressive myeloid cells to the lungs.
- Strong adhesion by regulatory T cells induces dendritic cell cytoskeletal polarization and contact-dependent lethargy
Chen et al. show that regulatory T cells adhere to dendritic cells (DCs) with high binding forces. This strong binding causes cytoskeletal polarization in the latter, which limits DCs’s ability to form productive engagement with other antigen-specific T cells.
- Class II MHC–independent suppressive adhesion of dendritic cells by regulatory T cells in vivo
Yan et al. demonstrate that in vivo T reg cells can form prolonged contacts with dendritic cells (DCs) in an MHC-independent manner and suppress the ability of the same DCs to contemporaneously engage in stable interactions with and activate conventional T cells.
- Peptidylarginine deiminase 4 promotes age-related organ fibrosis
Peptidylarginine deiminase 4 (PAD4) citrullinates proteins. In neutrophils, it causes chromatin decondensation and release of NETs, which are injurious. Martinod et al. show in this study that NETs promote fibrosis in a cardiac model and that PAD4-deficient mice have reduced age-related organ fibrosis.
- IKKα controls ATG16L1 degradation to prevent ER stress during inflammation
Decreased ATG16L1 stabilization is associated with increased susceptibility to develop inflammatory bowel diseases. Diamanti et al. identify IKKα as a central upstream kinase of ATG16L1, providing evidence that ATG16L1 stabilization is controlled by phosphorylation downstream of TNF and NOD activation.
- Deubiquitinase USP13 maintains glioblastoma stem cells by antagonizing FBXL14-mediated Myc ubiquitination
Fang et al. show that the deubiquitinase USP13 stabilizes c-Myc in glioblastoma stem cells (GSCs) by counteracting FBXL14-mediated Myc ubiquitination. c-Myc stabilization maintains GSC self-renewal and tumorigenic potential.