- Dissection of SAP-dependent and SAP-independent SLAM family signaling in NKT cell development and humoral immunity
Chen et al. dissect SAP-dependent and SAP-independent SLAM family signaling in the regulation of NKT cell development and follicular T helper cell differentiation using a novel mouse model lacking all seven SLAM family receptors.
- 5-hydroxytryptamine synthesized in the aorta-gonad-mesonephros regulates hematopoietic stem and progenitor cell survival
Lv et al. show that in mice, 5-HT can be synthesized in the aorta-gonad-mesonephros and acts as a novel endogenous regulator of hematopoietic stem and progenitor cell (HSPC) development. The promoting effect of 5-HT on the survival of HSPCs in the intraaortic hematopoietic cluster is mediated through Htr5a-AKT-Foxo1 signaling.
- Lipin-2 regulates NLRP3 inflammasome by affecting P2X7 receptor activation
Lordén et al. show that the phosphatidic acid phosphatase lipin-2 is a key regulator of the cellular machinery that generates IL-1β in macrophages. This work provides a molecular explanation for the development of the autoinflammatory disease known as Majeed syndrome.
- TRIM65-catalized ubiquitination is essential for MDA5-mediated antiviral innate immunity
Lang et al. identify E3 ligase TRIM65 as an essential component for the MDA-5 signaling pathway and provide solid evidence showing the importance of ubiquitination in MDA5 oligomerization and activation.
- Cell cycle progression dictates the requirement for BCL2 in natural killer cell survival
Natural killer (NK) cells eradicate virus-infected and transformed cells. Viant and colleagues describe the hierarchy of survival proteins and their apoptotic partners that govern NK cell survival. These data will inform approaches to harness NK cell activities in immunotherapies.
- Defective ATG16L1-mediated removal of IRE1α drives Crohn’s disease–like ileitis
Tschurtschenthaler et al. report a Crohn’s disease–like ileitis mediated by IRE1α that develops in mice with intestinal-epithelial Atg16l1 deletion when they age. The authors propose a selective autophagy process involved in the removal of IRE1α clusters during ER stress.
- Antibody-secreting plasma cells persist for decades in human intestine
This study provides a definite answer to the long-standing question concerning the longevity of the secretory antibody response. Landsverk et al. show that antigenic attrition affects a minor plasma cell subset and that distinct plasma cells are likely maintained for life in the human small intestine.
- Characterization of meningeal type 2 innate lymphocytes and their response to CNS injury
Immune responses to central nervous system (CNS) injuries are multifaceted, but their contributions are incompletely understood. Here, Gadani et al. describe type 2 innate lymphocytes as novel meningeal-resident cells, characterizing their transcriptional profile and response to CNS injury.
- CNS-targeted autoimmunity leads to increased influenza mortality in mice
Glenn et al. show that EAE induction impairs influenza immune responses, worsens influenza pathology, and is marked by early EAE-induced recruitment of suppressive myeloid cells to the lungs.