- Eros is a novel transmembrane protein that controls the phagocyte respiratory burst and is essential for innate immunity
Thomas et al. show that a novel protein, Eros, controls the abundance of components of the phagocyte NADPH oxidase, making it essential for the phagocyte respiratory burst and defense against common infections.
- Epithelial Fli1 deficiency drives systemic autoimmunity and fibrosis: Possible roles in scleroderma
Takahashi et al. find that epithelial cell–conditional knockdown of transcription factor Fli1 in mice drives systemic autoimmunity derived from thymic defects as well as selective tissue fibrosis in the skin and esophagus, mimicking human scleroderma. This study unravels the unanswered question about the origin of autoimmunity and selective tissue fibrosis in this disease.
- The transcription factor Foxo1 controls germinal center B cell proliferation in response to T cell help
Inoue et al. show that Foxo1 controls not only GC polarization but also GC B cell proliferation, the latter of which is mediated by Foxo1-dependent BATF up-regulation.
- AKR1B1 promotes basal-like breast cancer progression by a positive feedback loop that activates the EMT program
The treatment of BLBC represents an unmet medical need. Wu et al. show that AKR1B1 facilitates BLBC progression through a positive feedback loop that activates the EMT program, suggesting that inhibition of AKR1B1 has the potential to become a valuable therapeutic strategy for BLBC.
- CXCR1 remodels the vascular niche to promote hematopoietic stem and progenitor cell engraftment
Blaser et al. use live imaging of the zebrafish hematopoietic niche to show that cxcl8/cxcr1 signaling positively regulates HSPC engraftment by increasing HSPC-niche interactions, HSPC mitotic rate, niche size, and expression of cxcl12a in a niche-autonomous manner.
- Microglial complement receptor 3 regulates brain Aβ levels through secreted proteolytic activity
Czirr et al. report that microglia lacking complement receptor 3 display increased extracellular Aβ degrading activity and that targeting the receptor with a small molecule increases Aβ clearance in vivo, thus identifying a microglial receptor as a novel therapeutic target.
- Secretogranin III as a disease-associated ligand for antiangiogenic therapy of diabetic retinopathy
LeBlanc et al. uncover secretogranin III (Scg3) as a unique disease-associated vascular permeability and angiogenic factor using comparative ligandomics. Scg3-neutralizing antibodies alleviate vascular leakage in diabetic retinopathy mice and retinal neovascularization in oxygen-induced retinopathy mice with high efficacy.
- Impaired B cell function during viral infections due to PTEN-mediated inhibition of the PI3K pathway
Getahun et al. show that the inositol phosphatase PTEN plays a role in the inhibition of B cell functions observed during acute viral infections.