Newest Articles
Reactive species and pathogen antioxidant networks during phagocytosisThis review discusses the generation of phagosomal cytotoxic reactive species by activated macrophages and neutrophils for the control of intracellular pathogens, and the mechanisms by which microbes combat host-derived oxidants via antioxidant networks that mitigate the redox-dependent control of infection.
Die another way: Ferroptosis drives tuberculosis pathologyTuberculosis infection triggers ferroptosis
Interferon-induced guanylate-binding proteins: Guardians of host defense in health and diseaseThe role of guanylate-binding proteins in host defense.
rAAV-based brain slice culture models of Alzheimer’s and Parkinson’s disease inclusion pathologiesCroft et al. demonstrate the use of recombinant adeno-associated viruses and organotypic brain slice cultures to study the central nervous system. This strategy can be used to model Alzheimer’s and Parkinson’s disease inclusion pathologies and determine mechanisms underlying neurodegeneration and therapeutic targets.
FoxP3 and Ezh2 regulate Tfr cell suppressive function and transcriptional programTfr cells regulate Tfh-mediated antibody responses. Hou et al. demonstrate that FoxP3 and Ezh2 control the Tfr transcriptional program, and loss of this program results in dysfunctional ex-Tfr cells.
The developmental stage of the hematopoietic niche regulates lineage in MLL-rearranged leukemiaRowe and colleagues show that hematopoietic cells with MLL translocations undergoing leukemogenesis in neonatal mice yield mixed-lineage early B-lymphoid/myeloid leukemia while identical cells in adults generate myeloid leukemia, demonstrating that the age of the hematopoietic microenvironment impacts lineage.
Fibroblasts: Dangerous travel companionsFibroblasts form heterotypic aggregates with disseminating ovarian cancer cells, facilitating peritoneal metastasis.
Type I interferon induces CXCL13 to support ectopic germinal center formationDenton et al. show that during influenza infection of mice, type I interferon can induce CXCL13 de novo in pulmonary PGDFRα+ fibroblasts. This chemokine drives CXCR5-dependent recruitment of B cells to the lung, thereby supporting pulmonary germinal center formation.
Generation of pulmonary neuroendocrine cells and SCLC-like tumors from human embryonic stem cellsBy blocking an important signaling pathway (called NOTCH) and interfering with expression of two tumor suppressor genes in cells derived from human embryonic stem cells, Chen et al. have developed a model for studying small cell lung cancers.
Claudia Jakubzick: Work hard, play hardClaudia Jakubzick: Work hard, play hard