Newest Articles
Vaccines: An achievement of civilization, a human right, our health insurance for the futureThe value and social challenges of vaccination.
IL-17R–EGFR axis links wound healing to tumorigenesis in Lrig1+ stem cellsThis study provides mechanistic insight into how IL-17 receptor adopts EGFR to activate ERK5 axis in Lrig1+ stem cells for their proliferation and migration during wounding healing and tumorigenesis.
Inhibiting antibiotic-resistant Enterobacteriaceae by microbiota-mediated intracellular acidificationSorbara et al. report a critical function of the healthy intestinal microbiota in preventing the expansion of antibiotic-resistant Enterobacteriaceae that depends on the production of high levels of short chain fatty acids and an acidic environment to trigger intracellular acidification of Enterobacteriaceae.
Microbiome–microglia connections via the gut–brain axisA role for the gut microbiome in facilitating microglial maturation and shaping microglial physiology has emerged in recent years. This review highlights evidence demonstrating the various mechanisms by which the gut microbiota can influence microglia in both homeostatic and disease conditions.
Eran Elinav: Beyond the microbiomeEran Elinav: Beyond the microbiome
VEGF expands erythropoiesis via hypoxia-independent induction of erythropoietin in noncanonical perivascular stromal cellsGreenwald et al. show that VEGF can function as a potent hypoxia-independent inducer of erythropoietin in a population of VSMC-like perivascular stromal cells in a PDGFRβ-dependent manner, thereby expanding erythropoiesis by recruitment of additional cell types to the erythropoietin-producing cell pool.
Phosphatase Shp2 exacerbates intestinal inflammation by disrupting macrophage responsiveness to interleukin-10Appropriate macrophage responsiveness to IL-10 is crucial for the maintenance of gut immune homeostasis. Xiao et al. demonstrate that phosphatase Shp2 restrains IL-10–mediated deactivation of macrophages and thus supports the progression of intestinal inflammation.
Wnt5a induces and maintains prostate cancer cells dormancy in boneWnt5a from osteoblastic niche induces and maintains the dormancy of prostate cancer cells in bone and inhibits bone metastasis in a preventive manner, uncovering a potential therapeutic utility of Wnt5a in the treatment of bone metastatic prostate cancer.
Somatic activating mutations in PIK3CA cause generalized lymphatic anomalyGeneralized lymphatic anomaly (GLA) is a vascular disorder characterized by diffuse or multifocal lymphatic malformations (LMs). Here, Rodriguez-Laguna et al. report that somatic activating PIK3CA mutations can cause GLA, and we provide preclinical and clinical evidence to support the use of rapamycin for the treatment of GLA.
Toward a better understanding of folate metabolism in health and diseaseIn this review, Zheng and Cantley provide a historical perspective of the folate metabolism field, delve into folate chemistry that is often overlooked, and point out various missing links and underdeveloped areas in folate metabolism for future exploration.