Newest Articles
BCAP links IL-1R to the PI3K–mTOR pathway and regulates pathogenic Th17 cell differentiationDeason et al. discover a novel signaling adapter in the IL-1R pathway in CD4+ T cells that controls the induction of the PI3K–mTOR pathway, downstream of IL-1β, to induce pathogenic Th17 cells involved in the development of autoimmunity.
B cell adaptor for PI3-kinase (BCAP) modulates CD8+ effector and memory T cell differentiationSingh et al. show that expression of B cell adaptor for PI3-kinase (BCAP) is induced upon T cell activation and that this helps control effector and memory CD8+ T cell differentiation.
ARID5B regulates metabolic programming in human adaptive NK cells“Adaptive” NK cells expressing the activating receptor NKG2C expand and persist in HCMV-seropositive individuals. Cichocki et al. demonstrate enhanced oxidative and glycolytic metabolism for adaptive NK cells and implicate ARID5B as an important regulator of mitochondrial metabolism, IFN-γ production, and survival.
LPS inactivation by a host lipase allows lung epithelial cell sensitization for allergic asthmaThis study provides strong evidence that intestinal commensal LPS desensitizes lung epithelial cells and therefore diminishes allergic responses to inhaled allergens. A host lipase, acyloxyacyl hydrolase (AOAH), prevents the desensitization by inactivating commensal LPS.
Relationship between latent and rebound viruses in a clinical trial of anti–HIV-1 antibody 3BNC117In the setting of a clinical trial evaluating the anti–HIV-1 antibody 3BNC117, Cohen et al. demonstrate that rebound viruses that emerge following interruption of antiretroviral therapy are distinct from circulating latent viruses. Rebound viruses often appear to be recombinants between isolated latent viruses.
Transcription factor Etv6 regulates functional differentiation of cross-presenting classical dendritic cellsTranscriptional control of dendritic cell (DC) functions is poorly understood. Lau, Tiniakou, et al. report that transcription factor ETV6 optimizes gene expression in DCs and facilitates their ability to cross-prime T cells and initiate tumor-specific immune responses.
Microglial translational profiling reveals a convergent APOE pathway from aging, amyloid, and tauMicroglia are central players in homeostasis and disease. Kang et al. reveal a novel ApoE-driven microglial pathway shared between aging, amyloidosis, and tauopathy that is exacerbated in females, suggesting a convergent mechanism for altering microglial reactivity during Alzheimer’s disease.
Activated CARD11 accelerates germinal center kinetics, promoting mTORC1 and terminal differentiationB cell–intrinsic activated CARD11 (aCARD11) expression promotes rapid formation and premature collapse of the germinal center while enhancing terminal differentiation due to heightened NF-κB and mTORC1 signaling.
Identification of non-mutated neoantigens presented by TAP-deficient tumorsA hybrid forward-reversed immunological screen is performed to identify 16 novel HLA-A2 presented cancer antigens. These peptides are selectively presented by immune-escaped cancer cells with defects in the peptide transporter TAP. In contrast to mutated neoantigens, these “self” neoantigens are universally presented across different cancer types.
HPV: CIB1 is for EVER and EVERIn this issue, the Casanova group identifies bi-allelic loss-of-expression, loss-of-function mutations of the calcium- and integrin-binding protein 1 (CIB1) gene as a new cause of epidermodysplasia verruciformis (EV) and demonstrate that the CIB1 interacts with the EVER1 and EVER2 proteins to form a complex involved in keratinocyte-intrinsic immune response to human β-papillomaviruses (β-HPVs).