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Newest Articles

  • Regulation of amyloid-β dynamics and pathology by the circadian clock
    Regulation of amyloid-β dynamics and pathology by the circadian clock

    Circadian dysfunction is common in Alzheimer’s disease, but its role in disease pathogenesis is unknown. Kress et al. demonstrate that the circadian clock regulates daily rhythms in amyloid-β and that genetic disruption of clock function accelerates amyloid plaque accumulation in mice.

    Geraldine J. Kress, Fan Liao, Julie Dimitry, Michelle R. Cedeno, Garret A. FitzGerald, David M. Holtzman, Erik S. Musiek
    2018-01-30 06:30:57
  • <em>Irg1</em> expression in myeloid cells prevents immunopathology during <em>M. tuberculosis</em> infection
    Irg1 expression in myeloid cells prevents immunopathology during M. tuberculosis infection

    Nair et al. define a key role for Irg1 in minimizing the pathological immune response associated with Mtb infection. Using Irg1−/− and Irg1fl/fl conditional mice, detailed immune cell analysis, and transcriptional profiling, their data supports a model where Irg1 expression in myeloid cell subsets tempers inflammation and controls the recruitment and infection of neutrophils during Mtb infection.

    Sharmila Nair, Jeremy P. Huynh, Vicky Lampropoulou, Ekaterina Loginicheva, Ekaterina Esaulova, Anshu P. Gounder, Adrianus C.M. Boon, Elizabeth A. Schwarzkopf, Tara R. Bradstreet, Brian T. Edelson, Maxim N. Artyomov, Christina L. Stallings, Michael S. Diamond
    2018-03-06 05:11:15
  • Rab6-dependent retrograde traffic of LAT controls immune synapse formation and T cell activation
    Rab6-dependent retrograde traffic of LAT controls immune synapse formation and T cell activation

    Carpier et al. show that LAT trafficking to the immune synapse depends on endosome-to-Golgi/TGN retrograde transport and is controlled by Rab6 and Syntaxin-16. Moreover, they show that this retrograde pathway controls the TCR-induced activation of T lymphocytes.

    Jean-Marie Carpier, Andres E. Zucchetti, Laurence Bataille, Stéphanie Dogniaux, Massiullah Shafaq-Zadah, Sabine Bardin, Marco Lucchino, Mathieu Maurin, Leonel D. Joannas, Joao Gamelas Magalhaes, Ludger Johannes, Thierry Galli, Bruno Goud, Claire Hivroz
    2018-02-12 06:38:21
  • STAT-3–independent production of IL-17 by mouse innate-like αβ T cells controls ocular infection
    STAT-3–independent production of IL-17 by mouse innate-like αβ T cells controls ocular infection

    St. Leger et al. identify and examine innate-like αβ T cells that circumvent canonical STAT-3 phosphorylation to produce protective IL-17. These cells can exist in the ocular mucosa and protect the ocular surface from pathogenic Staphylococcus aureus infection.

    Anthony J. St. Leger, Anna M. Hansen, Hatice Karauzum, Reiko Horai, Cheng-Rong Yu, Arian Laurence, Katrin D. Mayer-Barber, Phyllis Silver, Rafael Villasmil, Charles Egwuagu, Sandip K. Datta, Rachel R. Caspi
    2018-02-28 05:42:50
  • Plasma cell output from germinal centers is regulated by signals from Tfh and stromal cells
    Plasma cell output from germinal centers is regulated by signals from Tfh and stromal cells

    Plasmablasts generated in germinal centers (GC) emerge at the GC–T zone interface (GTI). Zhang et al. demonstrate two major regulators of this process: Tfh-derived IL-21 and APRIL produced by CD157high fibroblastic reticular cells located in the GTI.

    Yang Zhang, Laura Tech, Laura A. George, Andreas Acs, Russell E. Durrett, Henry Hess, Lucy S.K. Walker, David M. Tarlinton, Anne L. Fletcher, Anja Erika Hauser, Kai-Michael Toellner
    2018-03-16 04:21:48
  • ZEB1, ZEB2, and the miR-200 family form a counterregulatory network to regulate CD8<sup>+</sup> T cell fates
    ZEB1, ZEB2, and the miR-200 family form a counterregulatory network to regulate CD8+ T cell fates

    Guan et al. identify genetic cooperativity between the transcription factor ZEB1 and the miR-200 family in memory CD8+ T cell development, which contrasts with that observed in the EMT. This study also shows that ZEB1 and its closely related homologue, ZEB2, play functionally distinct roles in CD8+ T cell differentiation.

    Tianxia Guan, Claudia X. Dominguez, Robert A. Amezquita, Brian J. Laidlaw, Jijun Cheng, Jorge Henao-Mejia, Adam Williams, Richard A. Flavell, Jun Lu, Susan M. Kaech
    2018-02-15 06:38:00
  • ADAM17 is required for EGF-R–induced intestinal tumors via IL-6 trans-signaling
    ADAM17 is required for EGF-R–induced intestinal tumors via IL-6 trans-signaling

    Schmidt et al. show that loss of the membrane-bound metalloprotease ADAM17 led to impaired intestinal cancer development in the murine APCmin/+ model, which also depended on IL-6 trans-signaling via the soluble IL-6R and could be blocked by the specific IL-6 trans-signaling inhibitor sgp130Fc.

    Stefanie Schmidt, Neele Schumacher, Jeanette Schwarz, Simone Tangermann, Lukas Kenner, Michaela Schlederer, Maria Sibilia, Markus Linder, Annelore Altendorf-Hofmann, Thomas Knösel, Elisabeth S. Gruber, Georg Oberhuber, Julia Bolik, Ateequr Rehman, Anupam Sinha, Juliane Lokau, Philipp Arnold, Anne-Sophie Cabron, Friederike Zunke, Christoph Becker-Pauly, Adele Preaudet, Paul Nguyen, Jennifer Huynh, Shoukat Afshar-Sterle, Ashwini L. Chand, Jürgen Westermann, Peter J. Dempsey, Christoph Garbers, Dirk Schmidt-Arras, Philip Rosenstiel, Tracy Putoczki, Matthias Ernst, Stefan Rose-John
    2018-02-22 07:06:15
  • 4-1BB costimulation induces T cell mitochondrial function and biogenesis enabling cancer immunotherapeutic responses
    4-1BB costimulation induces T cell mitochondrial function and biogenesis enabling cancer immunotherapeutic responses

    Tumor-infiltrating T cells experience metabolic repression that hinders their function and thus response to immunotherapy. Menk et al. show that ligation of 4-1BB, a TNFR family costimulatory molecule, can promote increased metabolic sufficiency, which enables intratumoral T cell function and response to immunotherapy.

    Ashley V. Menk, Nicole E. Scharping, Dayana B. Rivadeneira, Michael J. Calderon, McLane J. Watson, Deanna Dunstane, Simon C. Watkins, Greg M. Delgoffe
    2018-03-06 05:11:18
  • ApoE facilitates the microglial response to amyloid plaque pathology
    ApoE facilitates the microglial response to amyloid plaque pathology

    Increasing evidence suggests that apoE influences the innate immune response in neurodegeneration. Here, Ulrich et al. report that apoE influences amyloid plaque morphology and the microglial response to amyloid plaques, along with plaque-associated neuronal toxicity.

    Jason D. Ulrich, Tyler K. Ulland, Thomas E. Mahan, Sofie Nyström, K. Peter Nilsson, Wilbur M. Song, Yingyue Zhou, Mariska Reinartz, Seulah Choi, Hong Jiang, Floy R. Stewart, Elise Anderson, Yaming Wang, Marco Colonna, David M. Holtzman
    2018-02-26 06:00:14
  • Primary atopic disorders
    Primary atopic disorders

    Important insights from monogenic disorders into the immunopathogenesis of allergic diseases and reactions are discussed.

    Jonathan J. Lyons, Joshua D. Milner
    2018-03-16 04:21:47

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Print ISSN: 0022-1007

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