Table 3.

Evaluation of clinical signs and histological EAE in WT, IgHMOG-mem/JHT, and IgHMOG-ki mice

Ag and miceIncidenceOnsetMean maximal clinical scoreMean number of foci (±SEM)a
MeningesParenchymaTotal
MOG p35–55
WT15/1511.5 (±0.4)3.6 (±0.3)238 (±53)203 (±39)441 (±92)
IgHMOG-mem/JHT18/1811.4 (±1.1)3.7 (±0.3)117 (±23)117 (±24)234 (±47)
IgHMOG-ki15/1511.6 (±1.2)3.8 (±0.2)118 (±28)138 (±23)256 (±51)
rmMOG
WT15/1511.3 (±0.6)3.9 (±0.2)160 (±33)199 (±41)339 (±74)
IgHMOG-mem/JHT18/1811.4 (±0.2)3.9 (±0.2)189 (±18)199 (±12)388 (±30)
IgHMOG-ki15/1511.8 (±0.8)3.8 (±0.3)137 (±16)145 (±24)282 (±30)
rhMOG
WT18/1811.8 (±0.5)3.7 (±0.2)154 (±47)150 (±10)304 (±57)
IgHMOG-mem/JHT18/1811.8 (±0.7)3.0 (±0.2)118 (±28)139 (±23)257 (±51)
IgHMOG-ki17/1810.4 (±0.4)4.2 (±0.3)146 (±25)139 (±18)285 (±43)
  • Onset indicates mean day of disease onset (paralytic EAE) ± SEM. Clinical score shows mean maximal score of paralytic EAE of diseased mice ± SEM. Composite data from three independent experiments with five to six mice per group are indicated.

  • a The infiltration in the brain and spinal cord is quantified as averaged number of meningeal and parenchymal inflammatory foci (>10 clustered inflammatory cells) per CNS tissue section (five mice/group).