Table 1.

Analyses of plasma and feces from transgenic and littermate mice 12 d after DTX administration

ParameterLittermatesTransgenicsP-valueNormal range
Gamma glutamyl peptidase (U/liter)0.2 ± 0.20.0 ± 0.00.350.0–0.2
Aspartate aminotransferase (U/liter)150.0 ± 45.1167.2 ± 28.20.7559–247
Alanine aminotransferase (U/liter)24.4 ± 3.1114.6 ± 51.30.1228–132
Urea nitrogen (mmol/liter)7.2 ± 0.56.1 ± 0.60.796.4–10.4
Glucose (mmol/liter)15.0 ± 0.214.1 ± 0.80.389.0–19.3
Insulin (µg/liter)0.3 ± 0.10.3 ± 0.10.610.1–2.9
Albumin (g/liter)27.6 ± 2.026.6 ± 1.20.6825–48
Bilirubin (µmol/liter)6.4 ± 0.96.0 ± 1.00.782–15
Total protein (g/liter)51.0 ± 2.352.2 ± 0.60.6236–66
Phosphate (mmol/liter)2.1 ± 0.12.6 ± 0.20.101.97–3.26
Calcium (mmol/liter)2.0 ± 0.11.9 ± 0.10.261.47–2.35
Fecal energy (kJ/g)13.7 ± 0.713.7 ± 0.50.98
  • Data are representative of two independent analyses and are expressed as mean ± SEM (n ≥ 5). Fecal energy does not have a well-established normal range as it differs depending on chow so much. As a result, we have simply compared with littermate controls as these were fed at the same time with the same chow.