Table 1.

Blood flow, gases, and pH

StrainWT (n = 8)tsad−/− (n = 11)
mean ± SEMmean ± SEM
Mean arterial blood pressure (mmHg)85 ± 285 ± 5
Blood flow (ml/min g)
Pancreas caput1.64 ± 0.342.52 ± 0.33
Pancreas cauda1.38 ± 0.271.17 ± 0.27
Duodenum3.19 ± 0.604.50 ± 0.96
Colon2.34 ± 0.331.11 ± 0.28
Liver (hepatic artery)0.02 ± 0.010.10 ± 0.03
Kidneys4.38 ± 0.904.40 ± 1.07
Adrenal glands17.57 ± 4.2618.59 ± 4.95
Cerebrum0.74 ± 0.111.49 ± 0.46
White adipose tissue0.05 ± 0.010.01 ± 0.001
Lungs (= shunted blood)0.07 ± 0.040.04 ± 0.01
Blood gases and pHa
Blood pH7.25 ± 0.037.28 ± 0.04
PCO2 (kPa)6.37 ± 0.325.06 ± 0.62
Total CO2 (mmol/l)22.6 ± 1.219.0 ± 1.9
PO2 (kPa)13.75 ± 0.4611.85 ± 0.98
Oxygen saturation (%)96.2 ± 0.994.1 ± 1.0
S-HCO3- (mmol/l)21.0 ± 1.217.8 ± 1.6
S-Na+ (mmol/l)144 ± 1147 ± 1.0
S-K+ (mmol/l)5.6 ± 0.24.7 ± 0.2
Base excess (mmol/l)-6 ± 2-8 ± 1.0
Hemoglobin (g/liter)116 ± 4112 ± 5
  • a Both strains demonstrated slight anesthesia-induced hyperventilation (high PO2, low PCO2, low base excess, and low total CO2). There were no significant differences between the groups.