Table 1.

Demographic information

IDDurationAuto-AbAgeGenderEthnicityC peptideBMIHLA typing
yrng/ml
Recent onset cases
    Patient A<1 wkmIAA+ IA2ic+9FCaucasianundetectableN.D.A2, 25 B8 DR3,4
    Patient B1 wkmIAA+ GAD65+ IA2ic+5MCaucasianundetectableN.D.A2, 25 B8, 60 DR3, 4
    Patient C10 wkGAD65+24MCaucasian1.6122.9A3,29 B7,44 DR7,13
    Patient D6 moIA2ic+ GAD65 +14FCaucasian0.6520.1A2, 25 B8 DR3, 3
    Patient E9 moGAD65+ IA2ic+26FCaucasian1.1224.8A2,2 B18,44 DR3,4
Longstanding cases
    Patient 11 yrGAD65+ IA2ic+17FCaucasian0.921.2A2,25 B8 DR3,4
    Patient 21 yrICA512+ mIAA+ IA2ic+12MAfrican American0.1820.3A*0201, 6801 B*0602, 1502 DRB1*0901, 1602 DQA1*0102, 0301 DQAB1*0303, 0502
    Patient 33 yrGAD65+19MCaucasian0.3524.5A2,2 B18,44 DR3,3
    Patient 43 yrGAD65+19MCaucasian1.2NDA *0101, 0201, B*0801, 5101 DR*0301, 0404
    Patient 57 yrICA215+ mIAA+ IA-2ic+22FCaucasian<0.0521.6A*0201, 0205 B*3801, 5801 DRB1*1001, 1601 DQA1*0101, 0102 DQAB1*0501, 0502
    Patient 68 yrICA512+ ZnT8+ IA-2ic+18FCaucasian<0.0525.2A*0201, 0301 B*1501, 3901 DRB1*0101, 0401 DQA1*0101, 0301 DQAB1*0302, 0501
  • ICA512, islet cell autoantigen 512; ZnT8, zinc transporter 8; IA-2ic, intracytoplasmic domain of the tyrosine phosphatase IA-2; mIAA, micro assay for insulin autoantibodies; GAD65, Glutamic acid decarboxylase 65; ND, not determined