Table 1.

Primary genes induced by EGFR activation

Gene nameGene symbolAccession numberAffymetrix probe setFold change (EGF plus/minus)
Chemokine (C-C motif) ligand 2/MCP-1*CCL2NM_002982216598_s_at21.1147.014.94.9
Chemokine (C-C motif) ligand 8/MCP-2*CCL8NM_005623214038_at8.021.145.324.3
Guanine nucleotide binding protein (G protein), alpha 14GNA14NM_004297220108_at4.
Guanylate binding protein 1*GBP1NM_002053202269_x_at13.916.08.67.0
Guanylate binding protein 1*GBP1NM_002053202270_at9.813.96.18.0
Interleukin 6*IL6NM_000600205207_at16.
Interferon-induced protein with tetratricopeptide repeats 3*IFIT3NM_001031683204747_at3.
Interferon regulatory factor 1*IRF1NM_002198202531_at9.85.713.914.9
Interleukin 24IL24NM_006850206569_at12.16.510.63.7
Nuclear receptor subfamily 4, group A, member 3NR4A3NM_006981209959_at52.012.18.616.0
Suppressor of cytokine signaling 1*SOCS1NM_003745209999_x_at4.
Suppressor of cytokine signaling 3*SOCS3NM_003955206359_at5.73.255.748.5
Tenascin CTNCNM_002160216005_at9.85.37.511.3
  • The human HG-U133A Affymetrix arrays were performed twice in U87-EGFR and U178-EGFR cells with or without EGF stimulation. The genes whose expression was up-regulated more than threefold in all four sets of experiments are listed. The genes that could be grouped into an IFN-γ response gene module are indicated by an asterisk. Accession numbers are from GenBank/EMBL/DDBJ.