Table II.

Phenotype of cDCs and pDCs in pancreatic LNs from LCMV-infected Vα14 Ins-NP mice

Cell surface markercDCs (CD11c+120G8)pDCs (CD11c+120G8+)
Day 0Day 6Fold changeDay 0Day 6Fold change
CD80255 ± 20462 ± 11a1.81204 ± 36405 ± 18a1.98
CD86325 ± 33543 ± 18a1.67285 ± 19475 ± 31a1.67
CD40240 ± 18470 ± 41a1.95125 ± 12350 ± 20a2.80
I-Ag7 (MHC class II)824 ± 451,180 ± 37a1.43201 ± 43274 ± 51a1.36
PD-L1582 ± 231,056 ± 27a1.81219 ± 25738 ± 35a3.37
  • MFI was assessed on DC subsets in pancreatic LNs of Ins-NP Vα14 mice before and 6 d after LCMV infection. Results correspond to means ± SD of values obtained in four independent experiments with three pooled mice per group.

  • a P < 0.05 for day 6 compared with day 0.