Table I.

Genomic instability in WASP-I296T B and T cells

MetaphasesChromosome breaks>40 chromosomes per metaphase>40 chromosomes per nucleusOther
B cells
WT WASP510000
1310000
790000
WASP KO811000
710000
540020
WASP-I296T16031611 fused chromosome
732042 doublet chromosomes
561000
T cells
WT WASP500000
380000
720001 doublet chromosome
WASP-I296T390000
20617001 doublet chromosome
643101 doublet chromosome
  • Quantification of chromosomal aberrations in B and T cells. Each row represents an analysis of cells from one mouse. It was not possible to assess genomic instability in WASP-deficient T cells because they fail to proliferate in response to receptor activation.