Genomic instability in WASP-I296T B and T cells
| Metaphases | Chromosome breaks | >40 chromosomes per metaphase | >40 chromosomes per nucleus | Other | |
| B cells | |||||
| WT WASP | 51 | 0 | 0 | 0 | 0 |
| 131 | 0 | 0 | 0 | 0 | |
| 79 | 0 | 0 | 0 | 0 | |
| WASP KO | 81 | 1 | 0 | 0 | 0 |
| 71 | 0 | 0 | 0 | 0 | |
| 54 | 0 | 0 | 2 | 0 | |
| WASP-I296T | 160 | 3 | 16 | 1 | 1 fused chromosome |
| 73 | 2 | 0 | 4 | 2 doublet chromosomes | |
| 56 | 1 | 0 | 0 | 0 | |
| T cells | |||||
| WT WASP | 50 | 0 | 0 | 0 | 0 |
| 38 | 0 | 0 | 0 | 0 | |
| 72 | 0 | 0 | 0 | 1 doublet chromosome | |
| WASP-I296T | 39 | 0 | 0 | 0 | 0 |
| 206 | 17 | 0 | 0 | 1 doublet chromosome | |
| 64 | 3 | 1 | 0 | 1 doublet chromosome |
Quantification of chromosomal aberrations in B and T cells. Each row represents an analysis of cells from one mouse. It was not possible to assess genomic instability in WASP-deficient T cells because they fail to proliferate in response to receptor activation.