Table III.

Phenotype of transmitted HIV-1 clade C viruses compared with prototype clade B viruses

VirusasCD4HIVIGClade B plasmaClade C plasma17b21cb122G122F54E10Z13e1447-52D447-52D+ sCD4F425-B4e8F425-B4e8+ sCD430743074+ sCD4T-20T-1249Anti-CD4 mabTAK-779Co-receptor usage
nMµg/ml(IC50)b(IC50)cµg/mlµg/mlµg/mlµg/mlµg/mlµg/mlµg/mlµg/mlµg/mlµg/mlµg/mlµg/mlµg/mlµg/mlµg/mlµg/mlµM
YU-2136192020>10>107.16>50>50>50>5013.361.48>251.85>25>250.490.0940.180.047R5
NL4.316092310.210.590.011.080.241.05>500.030.01>25>25>25>250.470.0030.63>10X4
ADA1051,0001917>10>101.31>5033.2>50>50>250.03>250.11>256.810.150.0940.310.307R5
NL.Bal. ecto81135032>10>100.111.3912.315.1>500.140.040.540.05>251.470.090.0150.441.04R5
ZM246F1257481331>10>1021.35>50>505.50>50>25>25>25>25>253.350.070.0120.170.003R5
ZM247Fv1155>1,0001318>10>10>50>50>5011.33>50>25>25>25>25>25>250.050.0110.110.032R5
ZM247Fv2125>1,0001220>10>10>50>50>5047.11>50>25>25>25>25>25>250.080.0270.160.034R5
  • a Viruses derived by transfection of 293T cells with replication-competent molecularly cloned proviral DNA.

  • b Reciprocal geometric mean neutralization titers (IC50) of heterologous plasma specimens from 11 HIV-1 clade B chronically infected subjects.

  • c Reciprocal geometric mean neutralization titers (IC50) of heterologous plasma specimens from 22 HIV-1 clade C chronically infected subjects.