Table IV.

Somatic mutations in JH4-JH5 introns flanking VDJH4 rearrangements from splenic and blood B cell subsets

DonorsAge
 (months)TissueCD20-positive
 B cell
 subsetsNumber of sequencesMutations
TotalMutatedRangeNumberFrequency/
 total
 sequencesFrequency/
 mutated
 sequences
%%
D38spleenIgD+CD27+2110
 (48%)0–6230.320.67
IgDCD27+2019
 (95%)0–141051.541.55
bloodIgD+CD27+2012
 (60%)0–7370.540.90
IgDCD27+1813
 (72%)0–161031.672.32
D111bloodIgD+CD27+2015
 (75%)0–17791.161.54
IgDCD27+2018
 (90%)0–221171.711.90
D211bloodIgD+CD27+1815
 (83%)0–161161.892.27
IgDCD27+1716
 (94%)0–211272.192.32
D422spleenIgD+CD27+2512
 (48%)0–14400.511.09
IgDCD27+1413
 (93%)0–23911.902.05