Table IV.

OspA163–175 peptide binding of HLA-DRB1 genotypes in patients with antibiotic-refractory or antibiotic-responsive Lyme arthritis

DRB genotypesNumber of positive patientsOR (95% CI)P value
Antibiotic
 refractoryAntibiotic
 responsive
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Two known OspA-binding alleles versus two known nonbinding allelesn = 18n = 13
    (1) Both alleles bind15 (83)4 (31)11.3 (2.14, 58.8)0.008
    (2) Neither allele binds3 (17)9 (69)
One known OspA-binding allele versus one known nonbinding or
     unknown binding allelen= 53n= 37
    (3) One binding/one non- or unknown binding allelea41 (77)19 (51)3.2 (1.3, 8.0)0.013
    (4) One nonbinding/one unknown binding allele12 (23)18 (49)
All patientsn = 71n = 50
1 and 3: one or two known binding alleles56 (79)23 (46)4.4 (1.99, 9.66)<0.001
2 and 4: no known binding alleles15 (21)27 (54)
  • a Among the antibiotic-refractory patients, 22 had one known OspA-binding allele and one known non-OspA–binding allele, and 19 had one known OspA-binding allele and one allele that was not yet possible to test for binding. Among the antibiotic-responsive patients, 16 had a known OspA-binding allele and one known nonbinding allele, and three had one known OspA-binding allele and one allele that was not possible to test for binding.