Table II.

DRB1 allele frequencies in patients with antibiotic-refractory or antibiotic-responsive Lyme arthritis

DRB1aAllele frequenciesG value
Lyme arthritis patients
Antibiotic
 refractorybAntibiotic
 responsivec
%%
010111.344.1
01021.42.0
01030.743.1
030110.6140.6
040112.762.8
04022.80
04030.70
04046.360.0
04051.40
04072.10
040801
04090.70
041601
070112.090.5
08010.765.9
090101
11012.894.1
11020.70
11030.70
11041.475.0
12012.820.2
13014.240.0
13022.173.4
13032.130.2
14011.430.7
150114.191.3
15021.40
16012.120.0
Combined7.45
Total100.0100.031.9
P value0.006a
Degree of freedom15
Wn effect size
     statistic0.38
  • When less than or equal to five individuals with Lyme arthritis had a given haplotype, the values were excluded from analysis (empty cells). These rare alleles, which consisted of 7.4% of the total alleles in the refractory group and 5.0% of those in the responsive group, were excluded from the statistical analysis. Rare DRB1 alleles and their combined sum are listed in italics.

  • a For G statistic verification, the 2 × 15 table was also calculated by an exact test; P = 0.008.

  • b n = 142.

  • c n = 100.