Table I.

DRB1-DQA1-DQB1 haplotype frequencies in all patients with Lyme arthritis and in European-American control subjects or Lyme arthritis patients stratified by antibiotic response

DRB1-DQA1-DQB1Haplotype frequenciesG valueHaplotype frequenciesG value
European-American
 subjectsaAll Lyme arthritis
 patientsbLyme arthritis patients
Antibiotic
 refractorycAntibiotic
 responsived
%%%%
0101-0101-05019.17.90.410.643.5
0102-0101-05011.41.70.1
0103-0101-05010.52.16.70.743.1
0301-0501-020113.112.00.210.6140.6
0401-03-03015.46.60.67.750.7
0401-03-03024.93.31.34.913.2
0402-03-03021.01.70.9
0403-03-03020.401.9
0404-03-03023.95.00.65.050.0
0405-03-03020.30.81.5
0407-03-03010.91.20.3
0701-0201-020211.19.50.511.371.2
0701-0201-03033.71.25.0
0801-0401-04022.22.90.40.765.9
0901-03-03030.80.40.5
1001-0104-05030.70.03.3
1101-0501-03015.65.402.894.1
1103-0501-03010.30.40
1104-0501-03012.73.30.30.777.4
1201-0501-03011.12.52.92.820.2
1301-0103-06035.63.71.63.540.0
1302-0102-06043.42.50.62.130.2
1302-0102-06090.71.20.7
1303-0501-03010.72.55.62.130.2
1305-0501-03010.30.40.2
1401-0104-05032.01.70.1
1501-0102-060214.210.72.112.090.5
1501-0102-06032.10.82.2
1502-0103-06010.70.80.1
1601-0102-05021.02.12.22.120.0
Combinede1.33.712.020.0
Total100.0100.042.8100.0100.030.8
P value0.050.009f
Degree of freedom2915
Wn effect size statistic0.130.35
  • The 42 rare haplotypes that were found only in the control population are not shown here, but a complete listing of haplotypes in the control population has been published previously (19). Of the 13 rare haplotypes in patients with Lyme arthritis, 12 (0101-0102-0504, 0403-03-0304, 0408-03-0301, 0409-03-0301, 0416-03-0302, 1102-0501-0301, 1104-0101-0301, 1104-0103-0603, 1301-0103-0614, 1302-0102-0501, 1401-0104-0502, and 1501-0102-0502) were each found in only one patient, and one (0404-03-0402) was found in two patients. For comparison of the groups, 1.3% of the haplotypes in normal control subjects and 3.7% of those in all Lyme arthritis patients were excluded from analysis. For the analysis of patients by antibiotic response, 12% of those in the refractory group and 20% of those in the responsive group were excluded.

  • a n = 3,798.

  • b n = 242.

  • c n = 142.

  • d n = 100.

  • e When ≤5 individuals with Lyme arthritis or ≤10 individuals in the control population had a given haplotype, the values were excluded from analysis (empty cells).

  • f For log likelihood statistic verification, the 2 × 15 table was also calculated by an exact test; P = 0.01.