Table II.

Characteristics of PE-specific T cell clones from normal subjects

ClonePhenotypeCD1 restrictionCypress PE16:0/16:0 PE16:0/18:2 PE18:1/18:1 PE18:2/18:2 PE16:0/18:2 PGBrain PELiver PEEgg PE
NC-A2TCRαβ+CD4+CD161+CD1D+0+00++++0+++
NC-S22TCRαβ+CD4+CD1D++0++0++0++++
NC-D4TCRVα24+CD161+
 CD4CD8CD1D+0000++0++0
NC-F.1TCRαβ+CD4+CD1D+000+0++++++
NC-FP5TCRαβ+CD4+CD1D+0+0++0+++++
  • Antigen reactivity was measured by IL-4 production in 48 h culture supernatants: between 10 and 50 pg/ml (0), between 60 and 150 pg/ml (+), between 160 and 250 pg/ml (++), and over 260 pg/ml.