Table I.

Characteristics of phospholipid-specific T cell clones from cypress-sensitive subjects

ClonePhenotypeCD1 restriction
Cypress
 PC16:0/16:0
 PC16:0/18:2
 PC18:1/16:0
 PC18:1/18:1
 PC18:2/18:2
 PCBrain
 PCLiver
 PCEgg
 PC
1D3TCRαβ+CD4+CD1A++++0000++0+
1G5TCRαβ+CD4+CD1A+++0+00+++000
3F9TCRVαβ24+CD4+CD1A++++0000++0++
3G1TCRαβ+CD4+CD1D++0000+++000
5A2TCRαβ+CD4+CD1A++0+0+++++0+0
5B7TCRαβ+CD4+CD1A+++000+++0+0
5B9TCRαβ+CD4+CD1A+0000+++000
6D1TCRαβ+CD4+CD1D++0+00+++000
6D7TCRαβ+CD4+CD1A++0000++000
CD1Cypress
 PE16:0/16:0
 PE16:0/18:2
 PE18:1/18:1
 PE18:2/18:2
 PE16:0/18:2
 PGBrain
 PELiver
 PEEgg
 PE
B1.5TCRαβ+CD4+CD1D+++0+0++0000
C2TCRαβ+CD4+CD1D+++0+++++0000
D4TCRαβ+CD4+CD1D++0000+++000
E1.1TCRαβ+CD4+CD1D+++000++0000
F1TCRαβ+CD4+CD1D+++0++0++0000
F3TCRαβ+CD4+CD1D+++0000+++000
L5TCRαβ+CD4+CD1D+++0+++00000
S7TCRVα1+CD4+CD1D+++0+++0+000++
N3TCRVα24+CD161+CD4CD8CD1D++0++0++++00++
P3TCRαβ+CD4+CD1D++0++0+++0000
P13TCRαβ+CD4+CD1D++0000+++000
EA3TCRαβ+CD4+CD1D+++0+++0++000+
EA6TCRVδ1+CD161+CD1D+0++++0++00+0
FA3TCRαβ+CD4+CD161+CD1D+++0+0+++00+0
FA8TCRαβ+CD4+CD1D++0++0+++0000
GA10TCRαβ+CD4+CD1D+0++0++0000
DD6TCRαβ+CD4+CD161+CD1D++0000++000
DE10TCRαβ+CD4+CD1D++0++++0000
Q5TCRVδ1+CD4+CD161+CD1A++++0000++0++
  • Antigen reactivity was measured by IL-4 production in 48 h culture supernatants: between 10 and 50 pg/ml (0), between 60 and 150 pg/ml (+), between 160 and 250 pg/ml (++), and over 260 pg/ml (+++/++++).