Table III.

Frequencies of Ly49 and NKG2A receptors in single MHC class I mice

Receptor1Frequency of
 receptor2NK cells with
 down-regulated
 Ly493NK cells with
 down-regulated
 Ly49 or NKG2A4DRI5Weighted sum
 of DRI6
%%
Db mouse46688.5
Ly49G2557.7
Ly49A16 13.8
Ly49F117.2
Ly49C36 17.4
Ly49I58−0.1
NKG2A40N/A
Ld mouse638018.8
Ly49G255 23.2
Ly49A11 41.5
Ly49F 9 16.9
Ly49C3413.0
Ly49I59−7.3
NKG2A46N/A
Kb mouse383833.4
Ly49G247−0.2
Ly49A188.6
Ly49F8−3.0
Ly49C38 88.0
Ly49I47−9.6
NKG2A48N/A
Dd mouse758429.8
Ly49G249 21.9
Ly49A17 57.5
Ly49F 9 10.4
Ly49C36 23.4
Ly49I54−0.9
NKG2A38N/A
  • 1 Significantly down-regulated Ly49 receptors are in bold (see Fig. 5).

  • 2 Frequencies include all NK cells expressing the receptor, irrespective of any overlap with other receptors.

  • 3 The percentage of NK cells expressing any Ly49 receptor was calculated using the product rule to exclude counting NK cells expressing more than one Ly49 receptor twice. Only cells expressing a significantly down-regulated Ly49 receptors (bold) were included.

  • 4 The percentage of NK cells expressing either any down-regulated Ly49 receptor or NKG2A. NKG2A+ NK cells were included only when the ligand is present in the host (e.g., in Db, Ld, and Dd single mice).

  • 5 The DRI denotes the level of receptor down-regulation compared with the MHC mouse in percentage of mean fluorescence intensity.

  • 6 The weighted sum of DRI is the sum of individual DRI from significantly down-regulated Ly49 receptors (bold) multiplied by the indicated frequency of this receptor. The frequencies include all cells expressing the receptor, irrespective of any overlap with other receptors.