Table II.

Impaired development of alloantigen-reactive T reg cells in the absence of IFN-γ

Adoptive transfer
CD25+
CD45RBhighWild typeIFN-γ knockoutEvidence of necrosis
 between days 7 and 11
 (>50% of graft)Graft survival timeGraft survival at 100 d
d
+7/74 × 17, 21, 2 × 220/7
++3/917, 31, 46, 6× >1006/9
++9/92 × 17, 2 × 22, 2 × 31, 46, 94, 1001/9a