Table IV.

Phenotypical analysis of splenic leukocytes

1 × E6WTBak/Bax/Bim/Bak/Bim DKOBax/Bim DKO
n > 18n = 13n = 12n > 14n = 8n > 9
CD19+33.1 ± 3.132.9 ± 3.134.6 ± 2.354.5 ± 5.6a63.7 ± 8.1a57.3 ± 8.7a
CD3+20.8 ± 1.519.0 ± 1.717.8 ± 0.839.2 ± 3.2a26.6 ± 3.9b27.6 ± 3.9b
CD3+CD4+11.8 ± 0.98.8 ± 0.9a9.6 ± 0.817.2 ± 2.0a11.4 ± 1.310.8 ± 1.3b
CD3+CD8+5.9 ± 0.66.1 ± 0.85.1 ± 0.513.6 ± 1.8a8.2 ± 1.4b8.8 ± 1.1a,b
CD11b+Gr-1CD62L+/1.5 ± 0.11.3 ± 0.11.4 ± 0.32.0 ± 0.32.5 ± 0.91.8 ± 0.4
  • a P < 0.05 as compared with WT mice.

  • b P < 0.05 as compared with Bim−/− mice.

  • Quantitative analysis of lymphocytes and myeloid cells in spleen as determined by flow cytometry. All data are expressed as mean ± SE, which were compared by Student's t test.