Table I.

Comparison of 5′-NT Levels in Various Tissues

Tissue
 activityAPCP-inhibitable
 5′-NT activityNon-APCP
 5′-NT
Cd73+/+Cd73−/−Pooleda
nmol/h/mg ± SEMnmol/h/mg ± SEM
Colon1,523 ± 1169 ± 3b237 ± 41
Lung248 ± 5614 ± 4b73 ± 4
Heart171 ± 641 ± 0.1b33 ± 5
Muscle33 ± 56 ± 0.9bundetectable
Brain891 ± 12810 ± 6b89 ± 16
Liver347 ± 261 ± 0.1b40 ± 4
Kidney799 ± 1586 ± 4b90 ± 5
  • a Non-APCP inhibitable 5′-NT activity, pooled from both Cd73+/+ and Cd73−/− animals.

  • b Indicates significantly different than wild type (P < 0.001) for n = 7–9 mice per group.