Table I.

Flt3L Expands Lymphoid and Myeloid Progenitors In Vivo

5 Days10 DaysFold expansion
ControlFlt3L s.c.ControlFlt3L s.c.5 Days10 Days
percenttotal no. ×103percenttotal no. ×103percenttotal no. ×103percenttotal no. ×103
HSCa0.0317.50.1496.60.0316.20.0965.35.54
CLPa0.0312.50.0534.50.0210.80.04292.82.7
CMPa0.221100.714900.221190.483484.42.9
GMPa0.52503.52,4150.42161.91,3789.76.4
MEPa0.12600.1690.0843.20.06547.11.21.1
pB(A)a0.42000.53450.452431.81,3051.75.4
pB(BC)a1.57501.38971.58100.42901.20.36
pT1b0.02300.081040.02300.05603.52
pT2b0.071050.151950.06900.05601.90.7
  • a legs or

  • b thymus after 5 and 10 d of Flt3L or PBS injection, respectively. Results represent means of three to four animals per group and are representative of three independent experiments.

  • Relative percentages and total cell count of hematopoietic progenitor populations in bone marrow of two hind