Table II.

Cryptic RS Identified in VH Gene Segments by RIC12 Scores

Cryptic RS, RIC12 >−45
No.
 VH genesTotal<12 bp from
 3′ end of gene segmentFrequency of VH with
 cRS <12 bp from 3′ endc
Gene family
 (mouse nomenclature)MaHbMHMHMH
VH1(J558)144321012741260.30.8
VH2(Q52)5235295141.00.6
VH3(36-60)8883413250.40.3
VH4(X-24)2723162141.00.2
VH5(7183)3283152800.90.0
VH6(J606)4200
VH7(S107)8466630.80.8
VH8(3609)8200.0
VH9(VGAM3-8)9500.0
VH10(VH10)6661.0
VH11(CP3)1100.0
VH12(CH27)10
VH13(3609N)1100.0
VH14(SM7)4320.5
VH15NA10
  • a Mouse VH reference directory set (37) includes allelic variants.

  • b Human VH reference directory set (37) includes allelic variants.

  • c Frequency equals nos. cRS < 12 bp from 3′ end divided by no. VH genes.

  • RIC12 scores were computed for all 28-bp segments in mouse and human VH gene segments. The RIC12 scores were used to identify cRS embedded in the 3′ end of the gene segments. Some sequences contain multiple cRS.