Table I.

RSV Antibody and Viral Titers in Preimmunized Mice

After immunizationAfter challengeRSV titer
 (log pfu/g)
VaccinePRNTEIA FEIA GPRNTEIA FEIA G
FIRSV<10658 ± 22139 ± 12<10885 ± 18292 ± 163.96 ± 0.01
Placebo<10<50<50<10170 ± 2468 ± 43.98 ± 0.02
RSV IN164 ± 3833 ± 12148 ± 8205 ± 7971 ± 10261 ± 8<0.6
  • Antibody responses in BALB/c mice determined 28 d after immunization and 7 d after RSV challenge and RSV pulmonary titers 4 d after challenge. PRNT, RSV-specific neutralization as measured by 60% complement-enhanced plaque reduction; EIA-F, immunoassay determination of IgG antibodies against RSV F protein (change in absorbance); EIA G, immunoassay determination of IgG antibodies against RSV G protein (change in absorbance). Results are means ± SEM of 8–10 animals per group.