Table III.

Anti-NadA Antibody Passive Protection in Infant Rats Challenged with N. meningitidis Serogroup B Strains 8047 or 2996

Blood culture at 18 h
Exp.Strain(challenge CFU per rat)TreatmentSerum dilutionor dose of mAb(µg) per ratNo. positive/totalCFU/ml(geo. mean,103)
18047anticapsular mAb20/4<0.001
(7 × 103)anti-NadA antiserum1:50/4<0.001
PBS plus 1% BSA5/540.17
22996anticapsular mAb201/60.003
(5.6 × 103)anti-NadA antiserum1:51/60.002
anti-NadA antiserum1:253/60.035
preimmune NadA serum1:56/61.683