Table 2

Lack of Cytokine and Chemokine Secretion upon TREM-2 Engagement

F(ab′)2 anti–TREM-1F(ab′)2 anti–TREM-2LPS
IL-1αN.D.N.D.0.135 ± 0.026
IL-1β0.027 ± 0.012N.D.0.162 ± 0.09
TNF-α0.042 ± 0.005N.D.4.015 ± 0.078
IL-18N.D.N.D.2.56 ± 1.31
IL-6N.D.N.D.16.7 ± 5.43
IL-10N.D.N.D.2.03 ± 0.45
TGF-β1N.D.N.D.N.D.
IL-12p40N.D.N.D.3.48 ± 1.25
IL-12p70N.D.N.D.1.45 ± 0.09
IL-13N.D.N.D.N.D.
IL-15N.D.N.D.N.D.
MCP-12.018 ± 0.8750.449 ± 0.06798.18 ± 35.86
IL-81.23 ± 0.4510.023 ± 0.01124.76 ± 23.91
  • Cells were stimulated as described in Fig. 6. Cell supernatants were analyzed by ELISA for secretion of the indicated cytokines and chemokines. Data are representative for three independent experiments. Values are shown in pg/ml. N.D., not detectable.