Table 2

Responses of Diverse Strain Combinations to K/B×N Serum

CombinationStrain (F1)Max. clinical indexDay of onsetMax. ankle thickening
(mm)
Hi × HiBalb/c × PL41 (1)1.5
Hi × MBalb/c × NZW41 (1)1.4
Balb/c × MRL2.83.5 (2–5)1.0
Balb/c × B62.52.5 (2–3)0.9
Hi × LoBalb/c × SJL23.7 (3–4)0.8
PL × SJL1.15.8 (3–7)0.3
M × MB6 × NZW2.54 (4)1.6
B6 × MRL16.5 (6–7)0.4
M × LoNZW× C3H3.52.5 (2–3)1.6
B6 × C3H2.52.5 (2–3)0.8
NZW × SJL23.5 (1–6)1.1
B6 × SJL1.85 (3–7)0.3
Lo × LoC3H × SJL1.36 (5–7)0.1
M × NonB6 × NOD2.54.2 (2–7)1.0
NZW × NZB15.5 (4–7)0.2
  • Different strains of mice were transferred with 7.5 μl per gram body weight with serum from K/B×N mice on days 0 and 2. 2–10 mice were tested in each group. Mice were followed until day 7. In the “combination” column, Hi, M, Lo, and Non stand for high, moderate, low, and nonresponders, respectively. The “day of onset” is the first day of overt disease in one limb.