Table II.

Differential Effect of HIV on the Dynamics of T Cell Subpopulations and Monocytes

CD4CD8Monocytes
MeanSDrPMeanSDrPMeanSDrP
d1 (day−1)0.370.260.29NS0.410.26−0.10NS0.800.36−0.21NS
d2 (day−1)0.0360.0320.25NS0.0410.0390.14NSNANANANA
s1 (day−1)0.0160.0120.77<0.0010.0110.0100.81<0.0010.440.13−0.560.003
s2 (day−1)0.0090.0100.28NS0.0050.004−0.05NSNANANANA
  • Shown are the mean ± SD, of the calculated source (s) and the decay constant (d) for the two subpopulations of cells for lymphocytes and the single population for monocytes for 23 BrdU infusions (22 data sets for monocytes and CD8 T cells) in 17 patients as well as the correlation (Pearson correlation coefficient r) between d or s and log plasma viral RNA at the time of the infusion and the statistical significance of this correlation (P). NS, not significant (P > 0.05). One patient with unusually high (about one order of magnitude higher than the average, statistically an outlier) CD8 T cell turnover was excluded from the analysis. The inclusion of this patient decreases the correlation of s1 with HIV (r = 0.64) but it is still highly statistically significant (P = 0.002). The correlations were approximately the same when analyzing only the first infusion for all 17 patients. NA, not applicable.