Table I.

Expression and Modulation of Cytokine Receptor Chains in CD4+ Naive and Memory T Cell Subsets

(A) Cytokine receptor surface expression (MFI)a
T naiveTCMTEM
IL-6R14153
IL-10R4 (5)b7 (13)b7 (13)b
(B) αc chain surface expression (fold-induction)c
TNF-α2.521.5
IL-621.51
IL-10223.5
IL-121.51.52.5
TNF-α + IL-6 + IL-10434.5
  • a Unstimulated T cell subsets were stained with antibodies to IL-6R or IL-10R. Mean fluorescence index (MFI) after subtraction of the background is indicated.

  • b Values in parentheses indicate IL-10R expression after stimulation with IL-7 and IL-15 for 16 h.

  • c T cell subsets were cultured as in Fig. 4 and analyzed after 16 h for surface expression of ac chain. The fold-increase in MFI after subtraction of the background is shown.