Table 2

Decreased Numbers of B Cells in the Spleen of VpreB1−/−VpreB2−/− Mice

PopulationDaysNControl (mean ± SEM)NHomozygous (mean ± SEM)
Total10345.50 ± 9.57330.67 ± 4.06
50–706136.17 ± 10.80659.33 ± 10.45
B220+1039.63 ± 2.3831.10 ± 0
50–70644.83 ± 3.5369.88 ± 1.77
CD19+1039.20 ± 2.6030.99 ± 0.07
50–70643.80 ± 3.6568.90 ± 1.45
B220+IgM+1038.48 ± 2.1830.58 ± 0.06
50–70636.97 ± 3.1568.58 ± 1.33
B220+IgD+1037.49 ± 2.0230.39 ± 0.09
50–70639.82 ± 2.9867.96 ± 0.90
  • The mean and SEM of absolute numbers (× 106) are shown for the indicated cell populations in the spleen of control and homozygous VpreB1/VpreB2 double-mutant mice.