Table 1

Cytokine Production by CD25+CD4+ Tr Cells

StimuliCellsIL-2IL-4IL-10IFN-γTGF-β
αCD3/28 + IL-2CD25+ND153114857231322
αCD3/28 + IL-2CD25ND9484097731225
allogeneic APCsCD25+<19<9298527509
allogeneic APCsCD2599.5<92515744637
  • Purified cells were stimulated as indicated and supernatants were collected after 24 (for IL-2) or 72 h. The amount of cytokine was determined by ELISA. Data represent the average values (pg/ml) of pooled data from four independent experiments. Cytokine production by allogeneic APCs alone has been subtracted.