Table 1

Number of Cells Expressing NOS2 on Lung Sections of Persistently Infected Mice after Initiation of CD4+ T Cell Depletion Regimen

2 wk6 wk9 wk
Day 0GK1.5IgGGK1.5IgGGK1.5IgG
70 ± 1878 ± 17101 ± 8102 ± 11114 ± 33153 ± 25181 ± 18
P = 0.30P = 0.75P = 0.40
  • Beginning 6 mo after infection with M. tuberculosis, mice were treated with GK1.5 anti-CD4 antibody or control IgG. At the indicated time intervals after initiation of antibody treatment, lungs were recovered and immunohistochemically stained for NOS2 expression. The number of cells stained positively for NOS2 per 10 100× fields ± SE is shown. Three to five mice per time point per group were examined.