Table 1

Human DC1 Promotes Th2 versus Th1 Effectors in the Absence of IL-2 Expansion

RatioIFN-γIL-4
Experiment 11:42.80.2
1:3000.50.7
Experiment 21:43.80.15
1:3000.60.54
Experiment 31:42.00.1
1:3000.20.46
  • Naive T cells (106/ml) were stimulated for 6–7 d with mDCs activated by L-CD40L transfectants (Experiment 1 or 2) or SAC (Experiment 3) at 1:4 and 1:300 ratio. After washing, cells were restimulated with anti-CD3 immobilized on L-CD32/B7.1 L transfectants. Cytokines (in ng/ml) were measured after 24 h.