Table 1

CD25+CD45RBlowCD4+ but Not CD25CD45RBlowCD4+ Cells Inhibit Colitis

Cells injected
PhenotypeNo.Percentage of colitis (n)Percentage of weight change
CD45RBhighCD4+ alone89 (9)78.6 ± 4.9
CD45RBhighCD4+
Plus CD45RBlowCD4+2 × 1050 (5)103.3 ± 1.6
Plus CD25+CD45RBlowCD4+2 × 1050 (4)105.3 ± 0.8
1 × 1050 (4)107.0 ± 2.5
5 × 1040 (5)110.3 ± 2.5
Plus CD25CD45RBlowCD4+2 × 10538 (8)98.5 ± 5.0
5 × 10560 (10)8 6.7 ± 3.5
CD25+CD45RBlowCD4+ alone2 × 1050 (3)114.5 ± 6.9
CD25CD45RBlowCD4+ alone2 × 1050 (3)107.0 ± 0.6
  • SCID mice received 4 × 105 CD45RBhigh cells alone or in combination with other subpopulations as indicated. 8 wk after transfer, mice were killed and tissues were taken for histological examination. Data are pooled from two independent experiments. CD45RBhigh versus CD45RBhigh plus CD25+CD45RBlow: P < 0.001; CD45RBhigh versus CD45RBhigh plus CD25CD45RBlow: not significant.