Table 1

Nucleotide Substitution Preferences

To
FromBackgroundTCGATotal
TNormal8.34.04.016
Rag1−/−4.30.96.011
SCID5.22.83.211
CNormal154.63.322
Rag1−/−142.55.021
SCID2.34.01623
GNormal2.56.01322
Rag1−/−5.32.11623
SCID2.97.92334
ANormal127.01938
Rag1−/−8.79.52543
SCID126.51433
  • Single nucleotide substitutions on the Vκ sense strand are expressed as a percentage of the total number of mutations identified and have been corrected for base composition of the target. Database statistics are as follows: Normal, 303 mutations (none clonally related) in 118 sequences with 50 mutated sequences giving 6.1 mutations per mutated sequence; Rag1−/−, 108 mutations (6 clonally related) in 60 sequences with 21 mutated sequences giving 5.1 mutations per mutated sequence; SCID, 267 mutations (48 clonally related) in 95 sequences with 55 mutated sequences giving 4.9 mutations per mutated sequence.