Table 2

Induction of Vitiligo in AAD+Tyrosinase+ Mice by Adoptive Transfer of Tyrosinase-specific CTLs

CTLsOriginSpecificityHostIL-2Vitiligon
FMD 1Albino-AADAntityrosinaseAAD++++6
NoneNANAAAD+15
NoneNANAAAD6
M1B6-AADAnti- influenza M1AAD+12
CJLB6-AADAntityrosinaseAAD++++15
CJLB6-AADAntityrosinaseB6+2
CJLB6-AADAntityrosinaseAAD+6
  • All hosts were irradiated (700 rads) and received one of the regimens described above (see Materials and Methods). Vitiligo intensity was scored as the relative number of depigmented follicles within the 1-cm2 area of transfer. Mice were scored 4 wk after transfer as: −, none; +, <30%; +++, >70%. B6, C57BL/6.