Table 1

Plasma Cholesterol Levels in Study Mice

GenotypeTotal cholesterolHDL cholesterol
mg/dl ± SDmg/dl ± SD
apo E−/−CAM+/+ (n = 50)487 ± 15235 ± 14
apo E−/−ICAM-1−/− (n = 13)471 ± 12341 ± 17
apo E−/−P-selectin−/− (n = 19)495 ± 13445 ± 18
apo E−/−E-selectin−/− (n = 18)503 ± 13939 ± 15
  • Mice were fed a mouse chow diet from weaning until 20 wk of age, and plasma cholesterol was determined as described in Materials and Methods at 8, 12, 16, and 20 wk for all mice in the study (n = 100). There was no difference in cholesterol levels (Kruskal-Wallis nonparametric ANOVA) for the time points or sexes within each experimental group (CAM mutation), so they were combined. The amount of HDL cholesterol was determined using fast performance liquid chromatography for five mice in each group with no difference among groups. There was also no significant difference in the cholesterol levels for any experimental group of mice (Kruskal-Wallis).