Table 1

Regulation of Splenic DCs by Membrane LT but Not by Soluble LTα3 or TNF-α3

MiceTreatmentPercentage of Presence of
DCsT cellsFDCsT/B zones
wt2.4 ± 0.432 ± 6++
LTα2/−0.6 ± 0.234 ± 3
TNFR-I−/−3.7 ± 0.427 ± 3+
TNFα/−/−2.9 ± 0.532 ± 4+
wtLTβR–Ig0.9 ± 0.232 ± 8+
wtcontrol Ig2.6 ± 0.831 ± 9++
RAG-1−/−LTβR–Ig3.7 ± 0.2NA
RAG-1−/−control Ig11 ± 0.2NA
  • NA, not applicable due to the lack of T and B cells.