Table 1

Cycling Status and Absolute Numbers of Myeloid Progenitor Cells in Marrow and Spleen of +/+ and mev/mev Mice

Cycling rates of progenitors (% in S phase)Absolute No. progenitors (× 10−3)/organNucleated cellularity
CFU-GMBFU-ECFU-GEMMCFU-GMBFU-ECFU-GEMM
Marrow× 106
+/+27 ± 439 ± 338 ± 223.2 ± 2.62.8 ± 0.21.7 ± 0.222 ± 1.3
mev/mev54 ± 353 ± 659 ± 624.6 ± 2.22.4 ± 0.51.5 ± 0.214 ± 0
P value<0.001<0.04<0.004NS (<0.03)NS (>0.05)NS (>0.05)<0.001
Spleen
+/+10 ± 100 ± 00 ± 06.9 ± 2.13.5 ± 1.21.1 ± 0.3166 ± 14
mev/mev56 ± 255 ± 354 ± 457.8 ± 11.814.8 ± 4.86.4 ± 1.5279 ± 25
P value<0.001<0.001<0.001<0.002<0.001<0.02<0.002
  • Results are given as mean ± SEM for 10 +/+ and 10 mev/mev mice. Each mouse was assessed individually from a total of five separate experiments.