Table 1

Combination Treatment of B16-BL6 Using Anti–CTLA-4 Plus GM-CSF–producing Vaccine

Experiment no.B16-BL6 Day of challengeTreatment scheduleFraction of mice responding per treatment groupDepigmentation(fraction of responding mice)
Control IgGAnti–CTLA-4BL6/GM-CSF plus control IgGBL6/GM-CSF plus anti–CTLA-4
10A0/107/94/7
20A0/50/52/55/53/5
B5/53/5
C5/51/5
3−4A0/50/50/53/51/3
40A0/50/56/83/6
D2/53/52/3
50E0/50/50/52/52/2
F2/53/52/3
60A0/56/104/6
70A0/50/51/54/51/4
80A0/50/50/59/96/9
9−4A0/50/50/55/53/5
100A0/50/51/55/53/5
Total number of mice responding:0/550/358/5068/8536/68
Percentage:00168056