Table II

Protective Administration of IL-12 Reverses the Isotype Ratios But Suppresses Total Antibody Levels

IL-12 treatmentAmount of IL-12IgG1IgG2aIgG1/IgG2a ratioNumber of samples
(ng)(μg/ml)*(μg/ml)*
Early100  8,47619,7472.3320
 10166,95814,7530.09 8
  1275,749 2,4360.0112
Late100 43,081 6,3170.1511
None210,483 4,0890.0218
  • *  Calculated by averaging the titers of individually assayed serum samples.