Table 2

MCMV Recurrence in Mice after Combined Depletion of NK Cells and T Lymphocyte Subsets

mAb treatmentNo. of mice with recurrent infection (%)
Salivary glandsLungsSpleen
αNK  1/18 (5.6) 0/18 (0)0/18 (0)
αCD4 + αNK6/24 (25)1/24 (4.2)0/24 (0)
αCD8 + αNK 12/15 (80)13/15 (86.7)12/15 (80)
αCD4 + αCD8 + αNK25/25 (100)25/25 (100)22/25 (88)
  • Latently infected B cell–deficient mice (μMT/μMT) were depleted of NK cells, either alone or in combination with CD4+ and/or CD8+ T lymphocytes. 2 wk later, organs were analyzed for recurrent MCMV.