Table 3

Longitudinal Analysis of Spontaneous EAE in TCR-α/β Mutant Mice

StrainnObserved EAE*EAE onset before day 50‡EAE onset before day 60‡EAE onset before day 90‡Mortality due to EAE§
T/αβ15152 (13.3)13 (86.6)    15 (100)5 (33.3)
T/αβ+1716‖3 (17.6)    8 (47)13 (76.5)     0
T/α+β18123 (16.6) 7 (38.8)     9 (50)     0
  • *  Number of mice that developed EAE during the 160 d of observation.  

  •  Mice that developed EAE during the indicated time frame. Percentage is indicated in parentheses.  

  • §  Mice that died of EAE during the course of the experiment. Percentage is indicated in parentheses.  

  •  The only mouse that did not develop EAE died at 4 mo of age.