Table 2

Tumor Surface and Secreted Ig Isotypes

TumorSurface Ig*Secreted Ig‡Myc/Pvt 1 rearrangements§
C3H-gld
 142IgG2aIgG2a    ND‖
 205  NullIgG2aND
 217  IgG3     IgG3ND
 221  Null     IgAND
 223  IgG3     IgG3ND
 355  NullIgG2aND
 362  Null     IgG3ND
BALB-gld
 208  IgG1     IgG1ND
 311  Null     IgG3ND
 329  IgM     IgMND
 421  IgM     IgMND
 424  IgA     IgAND
 425IgG2aIgG2aND
 426  IgA     IgAND
 536  IgA     IgAND
 540IgG2aIgG2aND
  • *  Surface Ig expression on scid-passaged tumor cells determined by FACS® analysis.  

  •  Isotype of secreted Ig in sera from tumor-bearing scid mice determined by ELISA assay.  

  • §  Rearrangement of Myc and Pvt1 loci determined by Southern blot analysis of genomic DNA from scid-passaged tumors.  

  •  ND, not detected. Rearrangements of Myc or Pvt1 were not detected.