Table 3

Virus Titers of C57BL/6, P0/0, and P0/0/TNFR10/0 Mutants in Different Organs after Various Time Points of LCMV Infection

GenotypeDays after infection*Virus titer per ml or gram organ‡
BloodBone marrowSpleenThymusLiverKidney
PFUPFUPFUPFUPFUPFU
C57BL/6 81.0 × 102<105.2 × 1033.0 × 103<100<100
14<50<10<75<90<100<100
P0/0 83.4 × 1047.4 × 1031.8 × 1077.8 × 1051.9 × 1064.5 × 105
142.2 × 1046.7 × 1036.5 × 1072.8 × 1066.8 × 1072.1 × 106
P0/0/TNFR10/0 86.1 × 1046.7 × 1032.4 × 1079.7 × 1051.3 × 1063.1 × 105
146.3 × 1046.4 × 1036.0 × 1078.6 × 1065.6 × 1073.1 × 107
403.0 × 1033.0 × 1039.0 × 1052.1 × 1057.3 × 1051.1 × 106
903.3 × 1034.0 × 1024.9 × 1065.0 × 1056.8 × 1043.3 × 105
  • *  Mice were infected with a low dose of LCMV (2 × 102 PFU); organs were removed at the indicated time points after infection.  

  •  Viral titers of the various organs were determined individually in a focus-forming assay and are given as PFU per gram of tissue for solid organs. Blood titers are shown as PFU/ml and BM titers as PFU/107 nucleated BM cells. Data represent means of three to four mice. SD varied between 0.01 and 0.4 log10.